Evidence map›Paper›PMID 33266447›Full record

Trial reportNutrients2020

Twelve-Week Daily Consumption of

Morena Martucci, Maria Conte, Laura Bucci, Enrico Giampieri, Cristina Fabbri, Maria Giustina Palmas, Massimo Izzi, Stefano Salvioli, Angelo Vittorio Zambrini, Carla Orsi and 5 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Review
  6. Emerging Roles of Vitamin BInternational journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Morena MartucciDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Maria ConteDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-4621-9898
Laura BucciDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Enrico GiampieriDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Cristina FabbriDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Maria Giustina PalmasAlma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, 40126 Bologna, Italy.
Massimo IzziAlma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, 40126 Bologna, Italy.
Stefano SalvioliDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Angelo Vittorio ZambriniDepartment of Quality, Innovation, Safety, Environment, Granarolo S.p.A., 40057 Bologna, Italy.
Carla OrsiDepartment of Quality, Innovation, Safety, Environment, Granarolo S.p.A., 40057 Bologna, Italy.
Patrizia BrigidiUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.
Aurelia SantoroDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Miriam CapriDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
Daniela MontiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.ORCID 0000-0001-8651-8123
Claudio FranceschiDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.
University of Bologna · ITN. I. Lobachevsky State University of Nizhny Novgorod · RUUniversity of Florence · IT

Funding

Italian Ministry of Agriculture 00088MI01
6 · The paper itself

Abstract

BACKGROUND AND

aimA state of chronic, subclinical inflammation known as inflammaging is present in elderly people and represents a risk factor for all age-related diseases. Dietary supplementation with

methodsA double-blind randomized cross-over study was performed on forty-eight volunteers aged 63-80 years. The fortified milk was enriched with ω-3 polyunsaturated fatty acids (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA), vitamins (25-hydroxyvitamin D, E, C, B6, B9, B12), and trace elements (zinc, selenium). The two intervention periods lasted for 12 weeks, with a 16-week washout intermission.

resultsCompared to placebo, the consumption of fortified milk increased the circulating levels of different micronutrients, including vitamins and the ω-3 index of erythrocyte membranes. Conversely, it reduced the amount of arachidonic acid, homocysteine, and ω-6/ω-3 ratio.

conclusionTwelve-week daily consumption of

Indexed as

Food, FortifiedMilkAgedAged, 80 and overAnimalsCross-Over StudiesDouble-Blind MethodFatty Acids, Omega-3FemaleHealth StatusHumansInflammationMaleMicronutrientsMiddle AgedPlacebos25-hydroxyvitamin DFatty Acids, Omega-3MicronutrientsPlacebosVitamin B ComplexVitamin Dagingfortified milkhomocysteineω-3 indexω-6/ω-3 ratio

Identifiers

PMID33266447
PMCPMC7700442
OpenAlexW3109106474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.