Evidence map›Paper›PMID 33266419›Full record

ArticleInternational journal of molecular sciences2020

Mechanistic Insights into the Allosteric Regulation of the Clr4 Protein Lysine Methyltransferase by Autoinhibition and Automethylation.

Mina S Khella, Alexander Bröhm, Sara Weirich, Albert Jeltsch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Mina S KhellaInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.ORCID 0000-0003-2111-0375
Alexander BröhmInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Sara WeirichInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.
Albert JeltschInstitute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.ORCID 0000-0001-6113-9290
University of Stuttgart · DE

Funding

DAAD GERLS scholarship program funding program number 57311832Deutsche Forschungsgemeinschaft DFG JE 252/7-4
6 · The paper itself

Abstract

Clr4 is a histone H3 lysine 9 methyltransferase in

Indexed as

Protein Processing, Post-TranslationalAllosteric RegulationCatalytic DomainCell Cycle ProteinsHistone-Lysine N-MethyltransferaseHistonesKineticsMethylationSchizosaccharomycesSchizosaccharomyces pombe ProteinsCell Cycle Proteinsclr4 protein, S pombeHistone-Lysine N-MethyltransferaseHistonesSchizosaccharomyces pombe Proteinsautomethylationenzyme kineticsenzyme regulationprotein methylationprotein methyltransferase

Identifiers

PMID33266419
PMCPMC7700585
OpenAlexW3109496580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.