Evidence map›Paper›PMID 33266310›Full record

ReviewInternational journal of molecular sciences2020

The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington's Disease and Its Comorbidities.

Katie Andrews, Sunday Solomon Josiah, Jinwei Zhang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. "Molecular Shakers" as Transmembrane Single-Molecule Channels Toward 1:1 ClAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Restoring Compromised ClThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Article
  4. Neuronal KActa pharmacologica Sinica · 2024
    Review
  5. Therapeutic potential for KCC2-targeted neurological diseases.The Japanese dental science review · 2023
    Review
  6. Rett and Rett-related disorders: Common mechanisms for shared symptoms?Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  7. Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katie AndrewsInstitute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK.
Sunday Solomon JosiahInstitute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK.ORCID 0000-0001-8126-358X
Jinwei ZhangInstitute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK.ORCID 0000-0001-8683-509X
University of Exeter · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular chloride levels in the brain are regulated primarily through the opposing effects of two cation-chloride co-transporters (CCCs), namely K

Indexed as

Disease SusceptibilityAnimalsBiomarkersBrainComorbidityDrug DevelopmentHumansHuntington DiseaseK Cl- CotransportersMolecular Targeted TherapyNeuronsPhosphorylationSymportersBiomarkersK Cl- CotransportersSymportersChloride (Cl−) homeostasisGABAergicHuntington’s diseaseK+-2Cl− cotransporter 2 (KCC2)Na+-K+-2Cl− cotransporter 1 (NKCC1)sleep disorders

Identifiers

PMID33266310
PMCPMC7730145
OpenAlexW3109304011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.