Evidence map›Paper›PMID 33266221›Full record

ArticleInternational journal of molecular sciences2020

In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal.

Annalisa Maruca, Antonio Lupia, Roberta Rocca, Daniel Keszthelyi, Maura Corsetti, Stefano Alcaro

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Annalisa MarucaDipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0002-6537-552X
Antonio LupiaNet4Science Academic Spin-Off, Università "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0003-0870-2376
Roberta RoccaNet4Science Academic Spin-Off, Università "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0002-0680-7097
Daniel KeszthelyiDivision Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Universiteitssingel 50, 6229 HX Maastricht, The Netherlands.ORCID 0000-0001-9856-9980
Maura CorsettiNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK.ORCID 0000-0003-2957-4684
Stefano AlcaroDipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.
Magna Graecia University · ITMaastricht University · NLNottingham University Hospitals NHS Trust · GB

Funding

European Cooperation in Science and Technology CA16205 UngapMiur NUTRAMED PON 03PE000_78_2
6 · The paper itself

Abstract

Food-drug interaction is an infrequently considered aspect in clinical practice. Usually, drugs are taken together with meals and what follows may adversely affect pharmacokinetic and pharmacodynamic properties, and hence, the therapeutic effects. In this study, a computational protocol was proposed to explain the different assimilations of two

Indexed as

Dietary FatsDiet, High-FatFood-Drug InteractionsMealsFatsHumansImidazolesModels, MolecularMolecular ConformationMonte Carlo MethodPhenylalanineStatic ElectricityStructure-Activity RelationshipDietary FatseluxadolineFatsImidazolesPhenylalanineconformational analysiseluxadolinefood-drugs interactionsloperamidemolecular dynamics

Identifiers

PMID33266221
PMCPMC7731208
OpenAlexW3106654287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.