Evidence map›Paper›PMID 33266138›Full record

ArticleGenes2020

Using Personal Genomic Data within Primary Care: A Bioinformatics Approach to Pharmacogenomics.

Rick Overkleeft, Judith Tommel, Andrea W M Evers, Johan T den Dunnen, Marco Roos, Marie-José Hoefmans, Walter E Schrader, Jesse J Swen, Mattijs E Numans, Elisa J F Houwink

Abstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rick OverkleeftCoöperatie 4LifeSupport Europa u.a., 2321 JW Leiden, The Netherlands.
Judith TommelHealth, Medical and Neuropsychology Unit, Institute of Psychology, Faculty of Social and Behavioural Sciences, Leiden University, 2333 AK Leiden, The Netherlands.
Andrea W M EversHealth, Medical and Neuropsychology Unit, Institute of Psychology, Faculty of Social and Behavioural Sciences, Leiden University, 2333 AK Leiden, The Netherlands.
Johan T den DunnenDepartments of Human Genetics and Clinical Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Marco RoosHuman Genetics Department, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-8691-772X
Marie-José HoefmansSchluss, 1013 KS Amsterdam, The Netherlands.
Walter E SchraderGeneral Practitioner, 2313 AX Leiden, The Netherlands.
Jesse J SwenDepartment of Clinical Pharmacy and Toxicology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-3965-5552
Mattijs E NumansDepartment of Public Health and Primary Care (PHEG), Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands.
Elisa J F HouwinkDepartment of Public Health and Primary Care (PHEG), Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-9927-7266

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One application of personalized medicine is the tailoring of medication to the individual, so that the medication will have the highest chance of success. In order to individualize medication, one must have a complete inventory of all current pharmaceutical compounds (a detailed formulary) combined with pharmacogenetic datasets, the genetic makeup of the patient, their (medical) family history and other health-related data. For healthcare professionals to make the best use of this information, it must be visualized in a way that makes the most medically relevant data accessible for their decision-making. Similarly, to enable bioinformatics analysis of these data, it must be prepared and provided through an interface for controlled computational analysis. Due to the high degree of personal information gathered for such initiatives, privacy-sensitive implementation choices and ethical standards are paramount. The Personal Genetic Locker project provides an approach to enable the use of personal genomic data in primary care. In this paper, we provide a description of the Personal Genetic Locker project and show its utility through a use case based on open standards, which is illustrated by the 4MedBox system.

Indexed as

Computational BiologyElectronic Health RecordsGenetic TestingGenomicsHumansPharmacogeneticsPrecision MedicinePrimary Health CareethicsgenomicsPersonal Genetic Lockerpersonalized medicinepharmacogenomicsprimary careresearch

Identifiers

PMID33266138
PMCPMC7761137

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.