Evidence map›Paper›PMID 33266066›Full record

ArticleBiomolecules2020

A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors.

Diba Sheipouri, Casey I Gallagher, Susan Shimmon, Tristan Rawling, Robert J Vandenberg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Diba SheipouriSchool of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Casey I GallagherSchool of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Susan ShimmonSchool of Mathematical and Physical Sciences, University of Technology Sydney, Sydney, NSW 2007, Australia.
Tristan RawlingSchool of Mathematical and Physical Sciences, University of Technology Sydney, Sydney, NSW 2007, Australia.
Robert J VandenbergSchool of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia.
University of Sydney · AUUniversity of Technology Sydney · AU

Funding

Australian NHMRC APP144429
6 · The paper itself

Abstract

Reduced inhibitory glycinergic neurotransmission is implicated in a number of neurological conditions such as neuropathic pain, schizophrenia, epilepsy and hyperekplexia. Restoring glycinergic signalling may be an effective method of treating these pathologies. Glycine transporters (GlyTs) control synaptic and extra-synaptic glycine concentrations and slowing the reuptake of glycine using specific GlyT inhibitors will increase glycine extracellular concentrations and increase glycine receptor (GlyR) activation. Glycinergic neurotransmission can also be improved through positive allosteric modulation (PAM) of GlyRs. Despite efforts to manipulate this synapse, no therapeutics currently target it. We propose that dual action modulators of both GlyTs and GlyRs may show greater therapeutic potential than those targeting individual proteins. To show this, we have characterized a co-expression system in

Indexed as

Glycine AgentsGlycine Plasma Membrane Transport ProteinsReceptors, GlycineAnimalsGlycineHumansOocytesSynaptic TransmissionXenopus laevisGlycineGlycine AgentsGlycine Plasma Membrane Transport ProteinsReceptors, Glycineanalgesicsglycine receptorglycine transporterlipids

Identifiers

PMID33266066
PMCPMC7760315
OpenAlexW3095892940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.