ArticleCell reports2020
Nutrient Signaling, Stress Response, and Inter-organelle Communication Are Non-canonical Determinants of Cell Fate.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Polysome collapse and RNA condensation fluidize the cytoplasm.Molecular cell · 2024Article
- The cAMP-PKA signalling crosstalks with CWI and HOG-MAPK pathways in yeast cell response to osmotic and thermal stress.Microbial cell (Graz, Austria) · 2024Review
- When yeast cells change their mind: cell cycle "Start" is reversible under starvation.The EMBO journal · 2023Article
- Increased mesoscale diffusivity in response to acute glucose starvation.bioRxiv : the preprint server for biology · 2023Article
- Increased mesoscale diffusivity in response to acute glucose starvation.microPublication biology · 2023Article
- Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary.Biology open · 2023Article
- Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome.The Journal of cell biology · 2022Article
- Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease.Antioxidants (Basel, Switzerland) · 2022Review
- Sterol Metabolism Differentially Contributes to Maintenance and Exit of Quiescence.Frontiers in cell and developmental biology · 2022Article
- ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation.Molecular biology of the cell · 2022Article
- Connecting Timescales in Biology: Can Early Dynamical Measurements Predict Long-Term Outcomes?Trends in cancer · 2021Review
- Remodelling of Nucleus-Vacuole Junctions During Metabolic and Proteostatic Stress.Contact (Thousand Oaks (Ventura County, Calif.))Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Isogenic cells manifest distinct cellular fates for a single stress; however, the nongenetic mechanisms driving such fates remain poorly understood. Here, we implement a robust multi-channel live-cell imaging approach to uncover noncanonical factors governing cell fate. We show that in response to acute glucose removal (AGR), budding yeast undergoes distinct fates, becoming either quiescent or senescent. Senescent cells fail to resume mitotic cycles following glucose replenishment but remain responsive to nutrient stimuli. Whereas quiescent cells manifest starvation-induced adaptation, senescent cells display perturbed endomembrane trafficking and defective nucleus-vacuole junction (NVJ) expansion. Surprisingly, senescence occurs even in the absence of lipid droplets. Importantly, we identify the nutrient-sensing kinase Rim15 as a key biomarker predicting cell fates before AGR stress. We propose that isogenic yeast challenged with acute nutrient shortage contains determinants influencing post-stress fate and demonstrate that specific nutrient signaling, stress response, trafficking, and inter-organelle biomarkers are early indicators for long-term fate outcomes.
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