Evidence map›Paper›PMID 33264567›Full record

ArticlePharmaceutical biology2020

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.

Hongjie Wang, Boying Shan, Yulei Duan, Juan Zhu, Liping Jiang, Yang Liu, Yan Zhang, Feng Qi, Siyun Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hongjie WangSchool of Basic Medical Sciences, Hebei University, Baoding, China.
Boying ShanSchool of Basic Medical Sciences, Hebei University, Baoding, China.
Yulei DuanSchool of Basic Medical Sciences, Hebei University, Baoding, China.
Juan ZhuSchool of Basic Medical Sciences, Hebei University, Baoding, China.
Liping JiangSchool of Basic Medical Sciences, Hebei University, Baoding, China.
Yang LiuSchool of Basic Medical Sciences, Hebei University, Baoding, China.
Yan ZhangSchool of Basic Medical Sciences, Hebei University, Baoding, China.
Feng QiThe Department of Internal Medicine, Baoding No.1 Hospital, Baoding, China.
Siyun NiuSchool of Basic Medical Sciences, Hebei University, Baoding, China.
Hebei University · CNBaoding People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe Chinese herbal formula Heshouwu decoction (Heshouwuyin) has protective effects on testicular function in aging male rats, but the mechanism is unknown.

objectiveThis study investigated whether Heshouwuyin affects the testicular function of aging rats by regulating the insulin/IGF signalling pathway. MATERIALS AND

methodsSixteen-month-old male Wistar rats in the Heshouwuyin group and the natural-aging group were orally administered Heshouwuyin granules (0.056 g/kg) or equivalent normal saline for 60 d. The testicular tissue of 12-month-old male Wistar rats was removed as a young control group (

resultsThe immunofluorescence results revealed that the insulin receptor (INSR)- (0.056 ± 0.00548), insulin receptor substrate 1(IRS1)- (0.251 ± 0.031), IRS2 (0.230 ± 0.019)- and insulin-like growth factor 1 (IGF1)-positive cell rate (0.33 ± 0.04) in the aging group was higher than that in the young control group (0.116 ± 0.011, 0.401 ± 0.0256, 0.427 ± 0.031, 0.56 ± 0.031;

conclusionsOur research shows that Heshouwuyin can regulate the insulin/IGF signalling pathway to improve testicular function, and provides an experimental basis for further clinical use.

Indexed as

InsulinAnimalsCellular SenescenceDrugs, Chinese HerbalGene ExpressionInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMaleRatsRats, WistarReceptor, InsulinSertoli CellsSignal TransductionSpermatogenesisStem CellsTestisDrugs, Chinese HerbalheshouwuyinInsr protein, ratInsulinInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IReceptor, InsulinIGF1IGFBP3INSRIRS1IRS2Male reproductionsenescence

Identifiers

PMID33264567
PMCPMC7717869
OpenAlexW3109477689

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.