ArticlePloS one2020
Potency of gastrointestinal colonization and virulence of Candida auris in a murine endogenous candidiasis.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- In Vitro Acid Resistance of Feline-DerivedJournal of fungi (Basel, Switzerland) · 2026Article
- Article
- Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish (Aphanius dispar) infection.Communications biology · 2025Article
- A Novel and Robust Method for Investigating Fungal Biofilm.Bio-protocol · 2025Article
- Humans vs. Fungi: An Overview of Fungal Pathogens against Humans.Pathogens (Basel, Switzerland) · 2024Review
- Potential Activity of Micafungin and Amphotericin B Co-Encapsulated in Nanoemulsion against SystemicJournal of fungi (Basel, Switzerland) · 2024Article
- The many faces of Candida auris: Phenotypic and strain variation in an emerging pathogen.PLoS pathogens · 2024Review
- Tools and techniques to identify, study, and control Candida auris.PLoS pathogens · 2023Review
- A Novel Robust Method Mimicking Human Substratum To Dissect the Heterogeneity of Candida auris Biofilm Formation.Microbiology spectrum · 2023Article
- Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due toAntimicrobial agents and chemotherapy · 2023Article
- Intestinal colonization withFrontiers in immunology · 2023Article
- Review
- Commentary: Experimental Mouse Models of Invasive Candidiasis Caused byJournal of cellular immunology · 2022Article
- What Do We Know aboutMicroorganisms · 2021Review
- Diagnostic Allele-Specific PCR for the Identification ofJournal of fungi (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCandida auris infections have recently emerged worldwide, and this species is highly capable of colonization and is associated with high levels of mortality. However, strain-dependent differences in colonization capabilities and virulence have not yet been reported.
objectivesIn the present study, we aimed to clarify the differences between clinically isolated invasive and non-invasive strains of C. auris.
methodsWe evaluated colonization, dissemination, and survival rates in wild C57BL/6J mice inoculated with invasive or non-invasive strains of C. auris under cortisone acetate immunosuppression, comparing with those of Candida albicans and Candida glabrata infections. We also evaluated the potency of biofilm formation.
resultsStool fungal burdens were significantly higher in mice inoculated with the invasive strains than in those infected with the non-invasive strain. Along with intestinal colonization, liver and kidney fungal burdens were also significantly higher in mice inoculated with the invasive strains. In addition, histopathological findings revealed greater dissemination and colonization of the invasive strains. Regarding biofilm-forming capability, the invasive strain of C. auris exhibited a significantly higher capacity of producing biofilms. Moreover, inoculation with the invasive strains resulted in significantly greater loss of body weight than that noted following infection with the non-invasive strain.
conclusionsInvasive strains showed higher colonization capability and rates of dissemination from gastrointestinal tracts under cortisone acetate immunosuppression than non-invasive strains, although the mortality rates caused by C. auris were lower than those caused by C. albicans.
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