ArticlePLoS pathogens2020
Auxin response factors (ARFs) differentially regulate rice antiviral immune response against rice dwarf virus.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 98 citations in OpenAlex.
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- A plant NLR receptor activates auxin signaling through Aux/IAAs-ARF19 and YUC8-TIR1/AFBs to promote callose-mediated antiviral defense.Science advances · 2025Article
- JA-responsive R2R3-type MYB transcription factor OsMYB4P confers broad-spectrum antiviral immunity in rice.Plant biotechnology journal · 2025Article
- The microRNA OsmiR393 regulates rice brown planthopper resistance by modulating the auxin-ROS signaling cross-talk.Science advances · 2025Article
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- Genome-Wide Identification and Analysis of Auxin Response Factor Transcription Factor Gene Family inPlants (Basel, Switzerland) · 2025Article
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- Crop antiviral defense: Past and future perspective.Science China. Life sciences · 2024Review
- Functional Divergence of the Closely Related Genes PhARF5 and PhARF19a inInternational journal of molecular sciences · 2024Article
- Different viral effectors hijack TCP17, a key transcription factor for host Auxin synthesis, to promote viral infection.PLoS pathogens · 2024Article
- OsNAC121 regulates root development, tillering, panicle morphology, and grain filling in rice plant.Plant molecular biology · 2024Article
- CaIAA2-CaARF9 module mediates the trade-off between pepper growth and immunity.Plant biotechnology journal · 2024Article
- A comprehensive analysis of the WRKY family in soybean and functional analysis of GmWRKY164-GmGSL7c in resistance to soybean mosaic virus.BMC genomics · 2024Article
- ThePhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
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- AtSNP_TATAdb: Candidate Molecular Markers of Plant Advantages Related to Single Nucleotide Polymorphisms within Proximal Promoters ofInternational journal of molecular sciences · 2024Article
- Enigmatic role of auxin response factors in plant growth and stress tolerance.Frontiers in plant science · 2024Review
- Advances in auxin synthesis, transport, and signaling in rice: implications for stress resilience and crop improvement.Frontiers in plant science · 2024Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles in regulating myriad aspects of plant development, but their role (s) in host antiviral immune defense and the underneath mechanism remain largely unknown. By using the rice-rice dwarf virus (RDV) model system, here we report that auxin signaling enhances rice defense against RDV infection. In turn, RDV infection triggers increased auxin biosynthesis and accumulation in rice, and that treatment with exogenous auxin reduces OsIAA10 protein level, thereby unleashing a group of OsIAA10-interacting OsARFs to mediate downstream antiviral responses. Strikingly, our genetic data showed that loss-of-function mutants of osarf12 or osarf16 exhibit reduced resistance whereas osarf11 mutants display enhanced resistance to RDV. In turn, OsARF12 activates the down-stream OsWRKY13 expression through direct binding to its promoter, loss-of-function mutants of oswrky13 exhibit reduced resistance. These results demonstrated that OsARF 11, 12 and 16 differentially regulate rice antiviral defense. Together with our previous discovery that the viral P2 protein stabilizes OsIAA10 protein via thwarting its interaction with OsTIR1 to enhance viral infection and pathogenesis, our results reveal a novel auxin-IAA10-ARFs-mediated signaling mechanism employed by rice and RDV for defense and counter defense responses.
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