ArticleAnnals of clinical and translational neurology2021
Resection of piriform cortex predicts seizure freedom in temporal lobe epilepsy.
Article in Annals of clinical and translational neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Seizure Freedom Despite Piriform Cortex Sparing: Structural Connectivity Remodeling After SEEG-Guided Mesial Temporal RFTC.European journal of neurology · 2026Article
- No link between piriform cortex subregion resection and seizure freedom in two cohorts with temporal lobe epilepsy.Journal of neurology · 2026Article
- Piriform seizures mediated by the piriform-entorhino-dentate circuit induce brain-wide functional reorganization in mice.PLoS biology · 2026Article
- Utilization of the Cavitron Ultrasound Surgical Aspiration System in Resective Epilepsy Surgery.Current medical science · 2025Article
- Personalized neurometabolic signature predicts seizure outcomes of laser ablation in mesial temporal lobe epilepsy.Communications medicine · 2025Article
- Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery.Epilepsia · 2025Article
- Intraoperative magnetic resonance imaging during surgical resection for drug resistant epilepsy eliminates the incidence of inadvertent incomplete resection of the epileptogenic zone and early surgical failure.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Article
- Relationship of left piriform cortex network centrality with temporal lobe epilepsy duration and drug resistance.European journal of neurology · 2025Article
- Article
- The Alcatraz-Strategy: a roadmap to break the connectivity barrier in malignant brain tumours.Molecular oncology · 2024Review
- Olfactory Dysfunction and Limbic Hypoactivation in Temporal Lobe Epilepsy.Human brain mapping · 2024Article
- Interictal blood-brain barrier dysfunction in piriform cortex of people with epilepsy.Annals of clinical and translational neurology · 2024Article
- The involvement of the piriform cortex in non-lesional temporal lobe epilepsy: an uncommon component of the epileptogenic network.Brain communications · 2024Article
- Is there room in epilepsy for the claustrum?Frontiers in systems biology · 2024Article
- Practical microscopic neuroanatomy of the limbic system and basal forebrain identifiable on clinical 3T MRI.The neuroradiology journal · 2023Review
- Extent of piriform cortex resection in children with temporal lobe epilepsy.Annals of clinical and translational neurology · 2023Article
- Automatic and manual segmentation of the piriform cortex: Method development and validation in patients with temporal lobe epilepsy and Alzheimer's disease.Human brain mapping · 2023Article
- Subcellular analysis of blood-brain barrier function by micro-impalement of vessels in acute brain slices.Nature communications · 2023Article
- Towards network-guided neuromodulation for epilepsy.Brain : a journal of neurology · 2022Review
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTranssylvian selective amygdalo-hippocampectomy (tsSAHE) represents a generally recognized surgical procedure for drug-resistant mesial temporal lobe epilepsy (mTLE). Although postoperative seizure freedom can be achieved in about 70% of tsSAHE, there is a considerable amount of patients with persisting postoperative seizures. This might partly be explained by differing extents of resection of various tsSAHE target volumes. In this study we analyzed the resected proportions of hippocampus, amygdala as well as piriform cortex in regard of postoperative seizure outcome.
methodsBetween 2012 and 2017, 82 of 103 patients with mTLE who underwent tsSAHE at the authors' institution were included in the analysis. Resected proportions of hippocampus, amygdala and temporal piriform cortex as target structures of tsSAHE were volumetrically assessed and stratified according to favorable (International League Against Epilepsy (ILAE) class 1) and unfavorable (ILAE class 2-6) seizure outcome.
resultsPatients with favorable seizure outcome revealed a significantly larger proportion of resected temporal piriform cortex volumes compared to patients with unfavorable seizure outcome (median resected proportional volumes were 51% (IQR 42-61) versus (vs.) 13 (IQR 11-18), P = 0.0001). Resected proportions of hippocampus and amygdala did not significantly differ for these groups (hippocampus: 81% (IQR 73-88) vs. 80% (IQR 74-92) (P = 0.7); amygdala: 100% (IQR 100-100) vs. 100% (IQR 100-100) (P = 0.7)).
interpretationThese results strongly suggest temporal piriform cortex to constitute a key target resection volume to achieve seizure freedom following tsSAHE.
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