ArticleHippocampus2021
Theta power and theta-gamma coupling support long-term spatial memory retrieval.
Article in Hippocampus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review.Neuropsychology review · 2024Pooled it
- A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI).Brain structure & function · 2023Pooled it
- Modulation of prefrontal theta oscillations slows social cognition.Cognitive, affective & behavioral neuroscience · 2026Article
- Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval.Nature communications · 2026Article
- Hippocampal small RNAs from patients with schizophrenia induce specific cognitive and neural phenotypes in mice.Cell death discovery · 2026Article
- Opposing effects of slow and fast theta synchrony on working memory in the human hippocampal-orbitofrontal network.bioRxiv : the preprint server for biology · 2026Article
- Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice.The Journal of physiology · 2026Article
- Human hippocampal theta-gamma coupling coordinates sequential planning during navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Eye movements reflect memory-related theta activity in the human brain.PLoS biology · 2026Article
- A compound pulsed magnetic field achieves superior cognitive benefits against Alzheimer's disease progression via multi-level restoration of neural oscillations and cerebral perfusion.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- [Effects of 40 Hz light flicker stimulation on hippocampal-prefrontal neural activity characteristics during working memory tasks in Alzheimer's disease model rats].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Can Theta Burst Electromagnetic Fields Disrupt Learning in Planaria? Evidence of Impaired Fear-Conditioned Responses.Bioelectromagnetics · 2025Article
- Hippocampal LFP Responses during Pigeon Homing Flight in Outdoors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of alzheimer's disease.Scientific reports · 2025Article
- Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Memory-guided perception is shaped by dynamic two-stage theta- and alpha-mediated retrieval.Annals of the New York Academy of Sciences · 2025Article
- Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment.Frontiers in psychiatry · 2025Article
- Utilizing tACS to enhance memory confidence and EEG to predict individual differences in brain stimulation efficacy.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Toward a more comprehensive understanding of network centrality disruption in amnestic mild cognitive impairment: a MEG multilayer approach.Alzheimer's research & therapy · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Hippocampal theta oscillations have been implicated in spatial memory function in both rodents and humans. What is less clear is how hippocampal theta interacts with higher frequency oscillations to support long-term memory. Here we asked 10 presurgical epilepsy patients undergoing intracranial EEG recording to perform a long-term spatial memory task in desktop virtual reality and found that increased theta power in two discrete bands ("low" 2-5 Hz and "high" 6-11 Hz) during cued retrieval was associated with improved task performance. Similarly, increased coupling between "low" theta phase and gamma amplitude during the same period was associated with improved task performance. Finally, low and high gamma amplitude appeared to peak at different phases of the theta cycle; providing a novel connection between human hippocampal function and rodent data. These results help to elucidate the role of theta oscillations and theta-gamma phase-amplitude coupling in human long-term memory.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.