ReviewOdontology2021
Endodontic regeneration: hard shell, soft core.
Review in Odontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bioactive Restorative Materials.International dental journal · 2023Guideline
- Trial
- Trial
- Comparative study of articaine 4% versus lidocaine 2% in the local anesthesia of permanent mandibular first molars affected by MIH: a randomized controlled trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Trial
- Clinical Potential of Long-Term Cryopreserved Stem Cells From Impacted Third Molar Pulps for Regenerative Endodontic Procedures: An Ex Vivo Evaluation.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Bioactivity and dimensional stability of resin-, hybrid-, and silicate-based endodontic sealers: An in vitro comparative study.Journal of clinical and experimental dentistry · 2026Review
- Long-term outcomes of platelet-rich fibrin and blood clot scaffolds in regenerative endodontic treatment of traumatized immature maxillary incisors: An 80-month case report.Frontiers in dental medicine · 2026Article
- A bioactive composite of freeze-dried stem cells, porous microcarriers, and fibrinogen-thrombin gel for dental pulp tissue engineering.American journal of stem cells · 2026Article
- 3D visualization of neurovascular networks in pulp-exposed rat molars using tissue clearing techniques.Odontology · 2025Article
- Advanced Platelet-Rich Fibrin Plus Sealed Exclusively with Glass Ionomer Cement: Setting a New Standard for Healing, Aesthetics and Predictive Modelling in Regenerative Endodontics.Materials (Basel, Switzerland) · 2025Article
- Regenerative Endodontic Therapies: Harnessing Stem Cells, Scaffolds, and Growth Factors.Polymers · 2025Review
- Understanding dental pulp inflammation: from signaling to structure.Frontiers in immunology · 2024Review
- Engineering the Future of Dental Health: Exploring Molecular Advancements in Dental Pulp Regeneration.International journal of molecular sciences · 2023Article
- Bioactivity of Dental Restorative Materials: FDI Policy Statement.International dental journal · 2023Review
- A Compilation of Study Models for Dental Pulp Regeneration.International journal of molecular sciences · 2022Review
- Long-Term Effect of Modified Glass Ionomer Cement with Mimicked Biological Property of Recombinant Translationally Controlled Protein.Polymers · 2022Article
- Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells.International journal of molecular sciences · 2022Article
- Isolation of Endogenous TGF-β1 from Root Canals for Pulp Tissue Engineering: A Translational Study.Biology · 2022Article
- Effects of decellularized extracellular matrix derived from Jagged1-treated human dental pulp stem cells on biological responses of stem cells isolated from apical papilla.Frontiers in cell and developmental biology · 2022Article
- Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A loss of organs or the destruction of tissue leaves wounds to which organisms and living things react differently. Their response depends on the extent of damage, the functional impairment and the biological potential of the organism. Some can completely regenerate lost body parts or tissues, whereas others react by forming scars in the sense of a tissue repair. Overall, the regenerative capacities of the human body are limited and only a few tissues are fully restored when injured. Dental tissues may suffer severe damage due to various influences such as caries or trauma; however, dental care aims at preserving unharmed structures and, thus, the functionality of the teeth. The dentin-pulp complex, a vital compound tissue that is enclosed by enamel, holds many important functions and is particularly worth protecting. It reacts physiologically to deleterious impacts with an interplay of regenerative and reparative processes to ensure its functionality and facilitate healing. While there were initially no biological treatment options available for the irreversible destruction of dentin or pulp, many promising approaches for endodontic regeneration based on the principles of tissue engineering have been developed in recent years. This review describes the regenerative and reparative processes of the dentin-pulp complex as well as the morphological criteria of possible healing results. Furthermore, it summarizes the current knowledge on tissue engineering of dentin and pulp, and potential future developments in this thriving field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.