Evidence map›Paper›PMID 33263819›Full record

ArticleSleep & breathing = Schlaf & Atmung2021

Effects of nasal high flow on nocturnal hypercapnia, sleep, and sympathovagal balance in patients with neuromuscular disorders.

Anna Christina Meyer, Jens Spiesshoefer, Nina Christina Siebers, Anna Heidbreder, Christian Thiedemann, Hartmut Schneider, Andrew T Braun, Winfried Randerath, Peter Young, Michael Dreher and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Anna Christina Meyer *Department of Neurology with Institute for Translational Neurology, Münster University Hospital, Munster, Germany.
Jens Spiesshoefer *Department of Neurology with Institute for Translational Neurology, Münster University Hospital, Munster, Germany.
Nina Christina SiebersDepartment of Neurology with Institute for Translational Neurology, Münster University Hospital, Munster, Germany.
Anna HeidbrederDepartment of Neurology with Institute for Translational Neurology, Münster University Hospital, Munster, Germany.
Christian ThiedemannDepartment of Neurology with Institute for Translational Neurology, Münster University Hospital, Munster, Germany.
Hartmut SchneiderDivision of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin, Madison, WI, USA.
Andrew T BraunSleep Disorders Center, Bayview Hospital, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Winfried RanderathBethanien Hospital gGmbH Solingen, Solingen, Germany.
Peter YoungMedical Park Klinik Reithofpark, Bad Feilnbach, Germany.
Michael DreherDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH, Aachen, Germany.
Matthias BoentertDepartment of Neurology with Institute for Translational Neurology, Münster University Hospital, Munster, Germany. matthias.boentert@ukmuenster.de.ORCID http://orcid.org/0000-0001-6133-1397
University Hospital Münster · DEInnsbruck Medical University · ATJohns Hopkins University · USMarienhospital Stuttgart · DERWTH Aachen University · DEScuola Superiore Sant'Anna · ITUniversity of Cologne · DEUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn neuromuscular disorders (NMD), inspiratory muscle weakness may cause sleep-related hypoventilation requiring non-invasive ventilation (NIV). Alternatively, nasal high flow therapy (NHF) may ameliorate mild nocturnal hypercapnia (NH) through washout of anatomical dead space and generation of positive airway pressure. Ventilatory support by NIV or NHF might have favourable short-term effects on sympathovagal balance (SVB). This study comparatively investigated the effects of NHF and NIV on sleep-related breathing and SVB in NMD patients with evolving NH.

methodsTranscutaneous CO

resultsCompared with no treatment, NHF20 and NHF50 did not significantly change p

conclusionsNHF does not correct sleep-disordered breathing in NMD patients with NH. Both NHF and NIV exert no immediate effects on SVB.

Indexed as

AdultBlood PressureFemaleHeart RateHumansHypercapniaMaleMiddle AgedNeuromuscular DiseasesNoninvasive VentilationOxygen Inhalation TherapyPolysomnographySleepTreatment OutcomeHypercapniaNasal high flow therapyNeuromuscular disordersSympathetic driveTranslational respiratory physiology

Identifiers

PMID33263819
PMCPMC7708892
OpenAlexW3106700199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.