ArticleJournal of experimental botany2021
Auxin biosynthesis and cellular efflux act together to regulate leaf vein patterning.
Article in Journal of experimental botany, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Reticulate leaf venation in Pilea peperomioides is a Voronoi diagram.Nature communications · 2026Article
- JULGI coordinates vascular development and leaf patterning through non-cell-autonomous regulation of miR165/166.Nature communications · 2026Article
- Contact area and tissue growth dynamics shape synthetic juxtacrine signaling patterns.Biophysical journal · 2025Article
- The role of auxin transport through plasmodesmata in leaf vein canalization and patterning.Frontiers in plant science · 2025Article
- A CC-NB-ARC-LRR Gene Regulates Bract Morphology in Cotton.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Plant Growth Regulation in Cell and Tissue Culture In Vitro.Plants (Basel, Switzerland) · 2024Review
- Regulation of tissue growth in plants - A mathematical modeling study on shade avoidance response inFrontiers in plant science · 2024Article
- Recent advances in auxin biosynthesis and homeostasis.3 Biotech · 2023Review
- Study on the Interactions of Cyclins with CDKs Involved in Auxin Signal during Leaf Development by WGCNA inInternational journal of molecular sciences · 2023Article
- Effects of Low Temperature on Pedicel Abscission and Auxin Synthesis Key Genes of Tomato.International journal of molecular sciences · 2023Article
- Scaling relations for auxin waves.Journal of mathematical biology · 2022Article
- A genetic framework for proximal secondary vein branching in the Arabidopsis thaliana embryo.Development (Cambridge, England) · 2022Article
- Developmental regulation of leaf venation patterns: monocot versus eudicots and the role of auxin.The New phytologist · 2022Review
- CRISPR-Cas9-mediated mutagenesis of the SlSRM1-like gene leads to abnormal leaf development in tomatoes.BMC plant biology · 2022Article
- Modeling Plant Tissue Development Using VirtualLeaf.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The Arabidopsis ATP-Binding Cassette E protein ABCE2 is a conserved component of the translation machinery.Frontiers in plant science · 2022Article
- Shaping leaf vein pattern by auxin and mechanical feedback.Journal of experimental botany · 2021Article
- The Glycine-Rich Domain Protein GRDP2 Regulates Ovule Development via the Auxin Pathway inFrontiers in plant science · 2021Article
- Auxin-mediated regulation of vascular patterning in Arabidopsis thaliana leaves.Plant cell reports · 2018Review
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7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our current understanding of vein development in leaves is based on canalization of the plant hormone auxin into self-reinforcing streams which determine the sites of vascular cell differentiation. By comparison, how auxin biosynthesis affects leaf vein patterning is less well understood. Here, after observing that inhibiting polar auxin transport rescues the sparse leaf vein phenotype in auxin biosynthesis mutants, we propose that the processes of auxin biosynthesis and cellular auxin efflux work in concert during vein development. By using computational modeling, we show that localized auxin maxima are able to interact with mechanical forces generated by the morphological constraints which are imposed during early primordium development. This interaction is able to explain four fundamental characteristics of midvein morphology in a growing leaf: (i) distal cell division; (ii) coordinated cell elongation; (iii) a midvein positioned in the center of the primordium; and (iv) a midvein which is distally branched. Domains of auxin biosynthetic enzyme expression are not positioned by auxin canalization, as they are observed before auxin efflux proteins polarize. This suggests that the site-specific accumulation of auxin, as regulated by the balanced action of cellular auxin efflux and local auxin biosynthesis, is crucial for leaf vein formation.
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