Evidence map›Paper›PMID 33263705›Full record

ReviewRevista Brasileira de terapia intensiva

Oxidative stress and decreased tissue HSP70 are involved in the genesis of sepsis: HSP70 as a therapeutic target.

Maicon Machado Sulzbacher, Mirna Stela Ludwig, Thiago Gomes Heck

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Revista Brasileira de terapia intensiva. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maicon Machado SulzbacherGrupo de Pesquisa em Fisiologia, Departamento de Ciências da Vida, Universidade Regional do Noroeste do Estado do Rio Grande do Sul - Ijuí (RS), Brasil.ORCID http://orcid.org/0000-0002-9375-0745
Mirna Stela LudwigGrupo de Pesquisa em Fisiologia, Departamento de Ciências da Vida, Universidade Regional do Noroeste do Estado do Rio Grande do Sul - Ijuí (RS), Brasil.
Thiago Gomes HeckGrupo de Pesquisa em Fisiologia, Departamento de Ciências da Vida, Universidade Regional do Noroeste do Estado do Rio Grande do Sul - Ijuí (RS), Brasil.
Universidade Regional do Noroeste do Estado do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a systemic infection that causes multiple organ dysfunction. HSP70 is a protein responsive to cell stress, in particular oxidative stress. Therefore, this literature review sought to investigate the roles of HSP70 and oxidative stress in the pathophysiology of sepsis and the possibility of HSP70 as a therapeutic target. HSP70 exerts a protective effect when located in cells (iHSP70), and its decrease, as well as its increase in the extracellular environment (eHSP70), under oxidative stress is a biomarker of sepsis severity. In addition, therapies that increase iHSP70 and treatment with HSP70 promote sepsis improvement.

Indexed as

HSP70 Heat-Shock ProteinsSepsisBiomarkersHumansOxidative StressBiomarkersHSP70 Heat-Shock Proteins

Identifiers

PMID33263705
PMCPMC7853686
OpenAlexW3107255601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.