Evidence map›Paper›PMID 33263635›Full record

ReviewClinics (Sao Paulo, Brazil)2020

Update on the diagnosis and management of COVID-19 in pediatric patients.

Ana Paula de Carvalho Panzeri Carlotti, Werther Brunow de Carvalho, Cíntia Johnston, Alfredo Elias Gilio, Heloisa Helena de Sousa Marques, Juliana Ferreira Ferranti, Isadora Souza Rodriguez, Artur Figueiredo Delgado

Open access · goldAbstract readReview
In one paragraph

Review in Clinics (Sao Paulo, Brazil), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. The burden of global outbreaks: Photos of the daily lives of children with congenital Zika syndrome during the COVID-19 pandemic.Health expectations : an international journal of public participation in health care and health policy · 2023
    Article
  3. Article
  4. Medicina (Kaunas, Lithuania) · 2022
    Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ana Paula de Carvalho Panzeri CarlottiDepartamento de Puericultura e Pediatria, Hospital das Clinicas (HCFMUSP), Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, BR.ORCID 0000-0003-2760-8801
Werther Brunow de CarvalhoDepartamento de Pediatria, Instituto da Crianca e do Adolescente (ICR), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.ORCID 0000-0002-9164-616X
Cíntia JohnstonDepartamento de Pediatria, Instituto da Crianca e do Adolescente (ICR), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.ORCID 0000-0002-1504-9160
Alfredo Elias GilioDepartamento de Pediatria, Hospital Universitario, Faculdade de Medicina (FMUSP), Universidade de Sao Paulo, Sao Paulo, SP, BR.ORCID 0000-0002-7995-7299
Heloisa Helena de Sousa MarquesDepartamento de Pediatria, Instituto da Crianca e do Adolescente (ICR), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.ORCID 0000-0002-0940-7793
Juliana Ferreira FerrantiDepartamento de Pediatria, Instituto da Crianca e do Adolescente (ICR), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.ORCID 0000-0002-8726-4839
Isadora Souza RodriguezDepartamento de Pediatria, Instituto da Crianca e do Adolescente (ICR), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.ORCID 0000-0002-1992-5420
Artur Figueiredo DelgadoDepartamento de Pediatria, Instituto da Crianca e do Adolescente (ICR), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.ORCID 0000-0003-4362-9880
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the risk for developing severe disease and critical illness is much lower in children with COVID-19 than in adults. Multisystem inflammatory syndrome in children (MIS-C), a possible complication of COVID-19, has been described as a hyperinflammatory condition with multiorgan involvement similar to that in Kawasaki disease or toxic shock syndrome in children with evidence of SARS-CoV-2 infection. This review presents an update on the diagnostic methods for COVID-19, including reverse-transcriptase polymerase chain reaction (RT-PCR) tests, serology tests, and imaging, and summarizes the current recommendations for the management of the disease. Particular emphasis is placed on respiratory support, which includes noninvasive ventilation and invasive mechanical ventilation strategies according to lung compliance and pattern of lung injury. Pharmacological treatment, including pathogen-targeted drugs and host-directed therapies, has been addressed. The diagnostic criteria and management of MIS-C are also summarized.

Indexed as

COVID-19COVID-19 Drug TreatmentSystemic Inflammatory Response SyndromeChildHumansPandemicsSARS-CoV-2

Identifiers

PMID33263635
PMCPMC7688073
OpenAlexW3108620189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.