Evidence map›Paper›PMID 33263282›Full record

ArticleeLife2020

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins.

Chanjae Lee, Rachael M Cox, Ophelia Papoulas, Amjad Horani, Kevin Drew, Caitlin C Devitt, Steven L Brody, Edward M Marcotte, John B Wallingford

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 53 citations in OpenAlex.

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  16. Formation and function of multiciliated cells.The Journal of cell biology · 2024
    Review
  17. Article
  18. Article
  19. Ruvbl1 is Essential for Ciliary Beating duringDevelopment & reproduction · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chanjae LeeDepartment of Molecular Biosciences, University of Texas, Austin, United States.
Rachael M CoxDepartment of Molecular Biosciences, University of Texas, Austin, United States.
Ophelia PapoulasDepartment of Molecular Biosciences, University of Texas, Austin, United States.
Amjad HoraniDepartment of Pediatrics, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0002-5352-1948
Kevin DrewDepartment of Molecular Biosciences, University of Texas, Austin, United States.
Caitlin C DevittDepartment of Molecular Biosciences, University of Texas, Austin, United States.
Steven L BrodyDepartment of Medicine, Washington University School of Medicine, St. Louis, United States.
Edward M MarcotteDepartment of Molecular Biosciences, University of Texas, Austin, United States.ORCID 0000-0001-8808-180X
John B WallingfordDepartment of Molecular Biosciences, University of Texas, Austin, United States.ORCID 0000-0002-6280-8625
The University of Texas at Austin · USWashington University in St. Louis · US

Funding

REGULATION OF MOTILE CILIA ASSEMBLY IN LUNG DISEASER01HL128370 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, SUSAN K DUTCHER · 2015 to 2026
$6.9M
Mapping the CPLANE interactome, an extensive protein interaction network underlying human ciliopathiesR01HD085901 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE, John B Wallingford · 2016 to 2026
$6.2M
Proteomics and model organism humanization to decode human geneticsR35GM122480 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE · 2017 to 2026
$5.4M
Development and function in mucociliary epitheliaR01HL117164 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI John B Wallingford · 2013 to 2026
$4.7M
Cellular and Molecular Features of Gene Mutations in Primary Ciliary DyskinesiaR01HL146601 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2019 to 2022
$2.3M
The Role of Dynein Motor Mutations in Motile Cilia DiseaseK08HL150223 · NHLBI · WASHINGTON UNIVERSITY · PI HORANI, AMJAD · 2020 to 2024
$797k
Mapping the blood cell protein complexosomeR01DK110520 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI EMILI, ANDREW, MARCOTTE, EDWARD M · 2016 to 2018
$727k
Discovery and characterization of novel ciliopathy protein complexesK99HD092613 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI DREW, KEVIN · 2017 to 2018
$200k
NHLBI NIH HHS K08 HL150223NHLBI NIH HHS R01 HL117164NHLBI NIH HHS R01 HL128370NHLBI NIH HHS R01 HL146601NICHD NIH HHS HD085901NICHD NIH HHS K99 HD092613NICHD NIH HHS R01 HD085901NIDDK NIH HHS R01 DK110520NIGMS NIH HHS R35 GM122480NIH HHS HL117164NIH HHS K99 HD092613NIH HHS LRPNIH HHS R01 DK110520NIH HHS R01 HL128370NIH HHS R01 HL146601
6 · The paper itself

Abstract

Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly. Recent work demonstrates that axonemal dyneins, their specific assembly factors, and broadly-acting chaperones are concentrated in liquid-like organelles in the cytoplasm called DynAPs (Dynein Axonemal Particles). Here, we use

Indexed as

AnimalsAxonemal DyneinsCiliaCytoplasmImmunoprecipitationMass SpectrometryOrganellesTandem Affinity PurificationXenopus laevisAxonemal Dyneinsaxonemal dyneinscell biologyciliaciliopathyDynAPsliquid-like organelleprimary ciliary dykinesiaxenopus

Identifiers

PMID33263282
PMCPMC7785291
OpenAlexW3107559716

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.