Evidence map›Paper›PMID 33263278›Full record

ArticleeLife2020

Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation.

Sue Ann Koay, Stephan Thiberge, Carlos D Brody, David W Tank

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Working memory expands shared task representations in cortex.bioRxiv : the preprint server for biology · 2025
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  8. Scanning a compressed ordered representation of the future.Journal of experimental psychology. General · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sue Ann KoayPrinceton Neuroscience Institute, Princeton University, Princeton, United States.ORCID 0000-0002-9648-2475
Stephan ThibergeBezos Center for Neural Circuit Dynamics, Princeton University, Princeton, United States.ORCID 0000-0002-6583-6613
Carlos D BrodyPrinceton Neuroscience Institute, Princeton University, Princeton, United States.ORCID 0000-0002-4201-561X
David W TankPrinceton Neuroscience Institute, Princeton University, Princeton, United States.ORCID 0000-0002-9423-4267

Funding

Subcortical Neural Coding and DynamicsU19NS104648 · NINDS · PRINCETON UNIVERSITY · PI BRODY, CARLOS D · 2017 to 2021
$15.3M
Mechanisms of neural circuit dynamics in working memoryU01NS090541 · NINDS · PRINCETON UNIVERSITY · PI BIALEK, WILLIAM, BRODY, CARLOS D · 2014 to 2016
$3.1M
NINDS NIH HHS U01 NS090541NINDS NIH HHS U19 NS104648Simons Foundation 328057
6 · The paper itself

Abstract

How does the brain internally represent a sequence of sensory information that jointly drives a decision-making behavior? Studies of perceptual decision-making have often assumed that sensory cortices provide noisy but otherwise veridical sensory inputs to downstream processes that accumulate and drive decisions. However, sensory processing in even the earliest sensory cortices can be systematically modified by various external and internal contexts. We recorded from neuronal populations across posterior cortex as mice performed a navigational decision-making task based on accumulating randomly timed pulses of visual evidence. Even in V1, only a small fraction of active neurons had sensory-like responses time-locked to each pulse. Here, we focus on how these 'cue-locked' neurons exhibited a variety of amplitude modulations from sensory to cognitive, notably by choice and accumulated evidence. These task-related modulations affected a large fraction of cue-locked neurons across posterior cortex, suggesting that future models of behavior should account for such influences.

Indexed as

AnimalsBehavior, AnimalCerebral CortexChoice BehaviorDecision MakingDiscrimination, PsychologicalMaleMiceNeuronsParietal LobeVisual CortexVisual Perceptiondecision makingevidence accumulationmouseneurosciencevisual cortex

Identifiers

PMID33263278
PMCPMC7811404

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.