ArticleeLife2020
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 169 citations in OpenAlex.
- Research hotspots and emerging trends of macrophages in peripheral nerve injury: a bibliometric and visualization analysis.Frontiers in cellular neuroscience · 2026Pooled it
- Article
- Application ofActa histochemica et cytochemica · 2026Article
- SARM1 is required for macrophage immunophenotype switching that is essential for nerve repair.bioRxiv : the preprint server for biology · 2026Article
- Roles of the Complement System in Peripheral Nerve Injury and Repair.Bioengineering (Basel, Switzerland) · 2026Review
- Peripheral nerve injury reduces macrophage efferocytosis to facilitate neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The neuroimmune microenvironment of peripheral nerve injury: mechanisms, pathophysiology, and therapeutic implications.Frontiers in surgery · 2026Review
- An Integrated Multi-Tissue Single-Cell Transcriptomic Analysis Highlights the CCL2-CCR2 Signaling Pathway as a Potential Therapeutic Target in Neuropathic Pain.Journal of pain research · 2026Article
- Nicheformer: a foundation model for single-cell and spatial omics.Nature methods · 2025Article
- Article
- Dysregulated Resolution of Inflammation After Respiratory Viral Infections: Molecular Pathways Linking Neuroinflammation to Post-Viral Neuropathic Pain-A Narrative Review.International journal of molecular sciences · 2025Review
- Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.Science translational medicine · 2025Article
- Runx2 downregulates Lpl expression through super-silencer formation to alter lipid metabolism in Zhu Schwann cells after nerve injury.Cellular & molecular biology letters · 2025Article
- Deletion of murineScience translational medicine · 2025Article
- A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain?Brain, behavior, and immunity · 2025Article
- Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies.Nature communications · 2025Article
- The Neuroregenerative Effects of IncobotulinumtoxinA (Inco/A) in a Nerve Lesion Model of the Rat.International journal of molecular sciences · 2025Article
- Erythropoietin decreases apoptosis and promotes Schwann cell repair and phagocytosis following nerve crush injury in mice.Cell death & disease · 2025Article
- Molecular and cellular mechanisms underlying peripheral nerve injury-induced cellular ecological shifts: Implications for neuroregeneration.IBRO neuroscience reports · 2025Review
- Basic Pathological Mechanisms in Peripheral Nerve Diseases.International journal of molecular sciences · 2025Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 1 country.
Ashley L Kalinski *Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States.ORCID 0000-0001-7611-0810
Choya Yoon *Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States.
Lucas D Huffman *Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States.
Patrick C Duncker *Department of Neurology, University of Michigan Medical School, Ann Arbor, United States.
Rafi KohenDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States.
Ryan PassinoDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States.
Hannah HafnerDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States.
Craig JohnsonDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States.
Riki KawaguchiProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Kevin S CarbajalDepartment of Neurology, University of Michigan Medical School, Ann Arbor, United States.
Juan Sebastian JaraBurke Neurological Institute, White Plains, United States.
Edmund HollisBurke Neurological Institute, White Plains, United States.ORCID 0000-0002-4535-4668
Daniel H GeschwindProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0003-2896-3450
Benjamin M SegalDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, United States.
Roman J GigerDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States.ORCID 0000-0002-2926-3336
University of Michigan · USUniversity of California, Los Angeles · USBurke Medical Research Institute · USCornell University · USThe Ohio State University Wexner Medical Center · US
Funding
TRAINING IN CLINICAL AND BASIC NEUROSCIENCET32NS007222 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 1985 to 2026
$8.0MImmune mediated regeneration of retinal ganglion cell axons following optic nerve traumaR01EY028350 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEGAL, BENJAMIN M · 2017 to 2020
$1.5MA novel inflammatory cell with neuroprotective and neuroregenerative propertiesR01EY029159 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEGAL, BENJAMIN M · 2018 to 2022
$1.4MTraining Program in Translational ResearchT32GM113900 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P, NIKOLOVSKA-COLESKA, ZANETA · 2016 to 2020
$991kNEI NIH HHS R01 EY028350NEI NIH HHS R01 EY029159New York State Department of Health C33267GGNIGMS NIH HHS T32 GM113900NINDS NIH HHS T32 NS007222
Abstract
Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6C
Indexed as
Nerve RegenerationPhagocytosisAnimalsApoptosisCells, CulturedCytokine Receptor Common beta SubunitDisease Models, AnimalFemaleGanglia, SpinalGene Expression RegulationGene Regulatory NetworksGranulocyte-Macrophage Colony-Stimulating FactorInflammation MediatorsLeukocytesMacrophagesMaleCsf2ra protein, mouseCsf2rb protein, mouseCytokine Receptor Common beta SubunitGranulocyte-Macrophage Colony-Stimulating FactorInflammation MediatorsReceptors, Granulocyte-Macrophage Colony-Stimulating Factoraxon regenerationconditioning lesiondorsal root gangliaefferocytosismouseneurosciencesciatic nerve injuryscRNA sequencing
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.