ReviewInfection & chemotherapy2020
Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19.
Review in Infection & chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Relevance of Mediterranean diet as a nutritional strategy in diminishing COVID-19 risk: A systematic review.PloS one · 2024Pooled it
- Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial.European journal of medical research · 2021Trial
- Epigenetic Modulation by Vitamin C and in Prenatal Depression: Implications for Offspring Health.Current medical science · 2026Review
- Vitamin C: A Comprehensive Review of Its Role in Health, Disease Prevention, and Therapeutic Potential.Molecules (Basel, Switzerland) · 2025Review
- Unwinding the potentials of vitamin C in COVID-19 and other diseases: An updated review.Nutrition and health · 2023Review
- Review
- Protective roles of vitamin C and 5-aminosalicylic acid on reproduction in acrylamide intoxicated male mice.Saudi journal of biological sciences · 2023Article
- Baseline serum vitamin A and vitamin C levels and their association with disease severity in COVID-19 patients.Acta bio-medica : Atenei Parmensis · 2023Article
- Antioxidants and clinical outcomes of patients with coronavirus disease 2019: A systematic review of observational and interventional studies.Food science & nutrition · 2022Review
- Traditional Chinese medicine together with high-dose vitamin C improves the therapeutic effect of western medicine against COVID-19.American journal of translational research · 2022Article
- Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19.International journal of environmental research and public health · 2021Review
- Covid 19: Diet Composition and Health.Nutrients · 2021Review
- Protective Effects of Black Cumin (International journal of molecular sciences · 2021Review
- The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19.Diseases (Basel, Switzerland) · 2021Review
- Vitamins, supplements and COVID-19: a review of currently available evidence.Drugs in context · 2021Review
- Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure.Drug design, development and therapy · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin C, also known as L-ascorbic acid, is an essential vitamin with pleiotropic functions, ranging from antioxidant to anti-microbial functions. Evidence suggests that vitamin C acts against inflammation, oxidative stress, autophagy chaos, and immune dysfunction. The ability to activate and enhance the immune system makes this versatile vitamin a prospective therapeutic agent amid the current situation of coronavirus disease 2019 (COVID-19). Being highly effective against the influenza virus, causing the common cold, vitamin C may also function against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its associated complications. Severe infections need higher doses of the vitamin to compensate for the augmented inflammatory response and metabolic demand that commonly occur during COVID-19. Compelling evidence also suggests that a high dose of vitamin C (1.5 g/kg body weight) in inflammatory conditions can result in effective clinical outcomes and thus can be employed to combat COVID-19. However, further studies are crucial to delineate the mechanism underlying the action of vitamin C against COVID-19. The current review aims to reposition vitamin C as an alternative approach for alleviating COVID-19-associated complications.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.