ArticleFrontiers in bioengineering and biotechnology2020
Mechano-Biological Computer Model of Scaffold-Supported Bone Regeneration: Effect of Bone Graft and Scaffold Structure on Large Bone Defect Tissue Patterning.
Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- HAp/PLGA/Chitosan Scaffolds Fabricated by Freeze-Drying and 3D Printing for Bone Regeneration: In Vitro Evaluation and Finite Element Analysis.Biomimetics (Basel, Switzerland) · 2026Article
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- Rethinking osteocyte modelsFrontiers in bioengineering and biotechnology · 2026Review
- Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists.Bioactive materials · 2024Review
- Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds.Journal of functional biomaterials · 2023Article
- Article
- Triply Periodic Minimal Surface-Based Scaffolds for Bone Tissue Engineering: A Mechanical,Tissue engineering. Part A · 2023Article
- Article
- Histological and Histomorphometric Evaluation of Implanted Photodynamic Active Biomaterials for Periodontal Bone Regeneration in an Animal Study.International journal of molecular sciences · 2023Article
- Prediction of Bone Healing around Dental Implants in Various Boundary Conditions by Deep Learning Network.International journal of molecular sciences · 2023Article
- Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-basedFrontiers in bioengineering and biotechnology · 2023Article
- Computational design and evaluation of the mechanical and electrical behavior of a piezoelectric scaffold: a preclinical study.Frontiers in bioengineering and biotechnology · 2023Article
- Simulating the mechanical stimulation of cells on a porous hydrogel scaffold using an FSI model to predict cell differentiation.Frontiers in bioengineering and biotechnology · 2023Article
- An innovative additively manufactured implant for mandibular injuries: Design and preparation processes based on simulation model.Frontiers in bioengineering and biotechnology · 2022Article
- A 3DFrontiers in bioengineering and biotechnology · 2022Article
- The Degradation of Synthetic Polymeric Scaffolds With Strut-like Architecture Influences the Mechanics-dependent Repair Process of an Osteochondral DefectFrontiers in bioengineering and biotechnology · 2022Article
- PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: AnFrontiers in bioengineering and biotechnology · 2022Article
- A mechanobiological computer optimization framework to design scaffolds to enhance bone regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration - an in silico analysis.Biomechanics and modeling in mechanobiology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large segmental bone defects represent a clinical challenge for which current treatment procedures have many drawbacks. 3D-printed scaffolds may help to support healing, but their design process relies mainly on trial and error due to a lack of understanding of which scaffold features support bone regeneration. The aim of this study was to investigate whether existing mechano-biological rules of bone regeneration can also explain scaffold-supported bone defect healing. In addition, we examined the distinct roles of bone grafting and scaffold structure on the regeneration process. To that end, scaffold-surface guided migration and tissue deposition as well as bone graft stimulatory effects were included in an
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