ReviewClinical, cosmetic and investigational dermatology2020
Honey Combination Therapies for Skin and Wound Infections: A Systematic Review of the Literature.
Review in Clinical, cosmetic and investigational dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Phytochemical Profiling and Antibacterial Activity of Moroccan Monofloral Honeys Against Multidrug-Resistant Uropathogens: In Vitro, ADMET, Molecular Docking, and Molecular Dynamics Approaches.Food science & nutrition · 2026Article
- Development and preclinical evaluation of an Aceh kelulut honey-based hydrocolloid dressing for wound healing.Narra J · 2026Article
- Clinical and Postoperative Applications of Manuka Honey in Wound Healing: An Evidence-Based Review.International wound journal · 2026Review
- Application of Honey Dressing in the Management of Postoperative Wounds, Ulcers, and Burns: A Systematic Review.Cureus · 2026Review
- Antimicrobial Peptides for Skin Wound Healing.Biomolecules · 2025Review
- Honey as a Natural Antimicrobial.Antibiotics (Basel, Switzerland) · 2025Review
- Linoleic Fatty Acid from Rwandan Propolis: A Potential Antimicrobial Agent AgainstCurrent issues in molecular biology · 2025Article
- Identification of 2,4-Di-Antibiotics (Basel, Switzerland) · 2024Article
- Imidazoles and Quaternary Ammonium Compounds as Effective Therapies against (Multidrug-Resistant) Bacterial Wound Infections.Antibiotics (Basel, Switzerland) · 2024Article
- Article
- Healing Effect of a Nano-Functionalized Medical-Grade Honey for the Treatment of Infected Wounds.Pharmaceutics · 2023Article
- Use of Medical-Grade Honey to Treat Clinically Infected Heel Pressure Ulcers in High-Risk Patients: A Prospective Case Series.Antibiotics (Basel, Switzerland) · 2023Article
- Ameliorative effects of propolis upon reproductive toxicity in males.Clinical and experimental reproductive medicine · 2023Article
- Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration.Polymers · 2023Article
- Honey dressing: a missed way for orthopaedic wound care.International orthopaedics · 2022Article
- Propolis: An update on its chemistry and pharmacological applications.Chinese medicine · 2022Review
- Antibacterial interactions between two monofloral honeys and several topical antiseptics, including essential oils.BMC complementary medicine and therapies · 2022Article
- Role of Honey in Advanced Wound Care.Molecules (Basel, Switzerland) · 2021Review
- Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties.Frontiers in nutrition · 2021Review
- Alternative Approaches for the Management of Diabetic Foot Ulcers.Frontiers in microbiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topical application of medical grade honey is recommended for the clinical management of wound infections. The suitability of honey as a wound healing agent is largely due to its antibacterial activity, immune modulatory properties, and biocompatibility. Despite the usefulness of honey in wound healing, chronic wound infections continue to be a global problem requiring new and improved therapeutic interventions. Several recent studies have investigated the effects of combining honey with other therapies or agents with the aim of finding more efficacious treatments. In this systematic review, the database PubMed was used to carry out a search of the scientific literature on the combined effects of honey and other therapies on antimicrobial activity and wound and skin healing. The search revealed that synergistic or additive antimicrobial effects were observed in vitro when honey was combined with antibiotics, bacteriophages, antimicrobial peptides, natural agents, eg, ginger or propolis and other treatment approaches such as the use of chitosan hydrogel. Outcomes depended on the type of honey, the combining agent or treatment and the microbial species or strain. Improved wound healing was also observed in vivo in mice when honey was combined with laser therapy or bacteriophage therapy. More clinical studies in humans are required to fully understand the effectiveness of honey combination therapies for the treatment of skin and wound infections.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.