ArticleInternational journal of nanomedicine2020
Impacts of a Nano-Laponite Ceramic on Surface Performance, Apatite Mineralization, Cell Response, and Osseointegration of a Polyimide-Based Biocomposite.
Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Polyimide as a biomedical material: advantages and applications.Nanoscale advances · 2024Review
- ZIF-8 induced hydroxyapatite-like crystals enabled superior osteogenic ability of MEW printing PCL scaffolds.Journal of nanobiotechnology · 2023Article
Corrections and comments
- Retracted
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPolyimide (PI) exhibits good biocompatibility and high mechanical strength, but biological inertness that does not stimulate bone regeneration, while laponite possesses excellent bioactivity.
methodsIn this study, to improve the bioactivity of PI, nano-laponite ceramic (LC)-PI composites (LPCs) were fabricated by melt processing as implantable materials for bone repair.
resultsThe compressive strength, hydrophilicity, and surface roughness of LPCs with 40 w% LC content (LPC40s) were higher than LPC20s, and LPC20s higher than pure PI. In addition, no apatite mineralization occurred on PI, while apatite mineralized on LPCs in simulated body fluid. Compared with LPC20, more apatite deposited on LPC40, indicating good bioactivity. Moreover, the adhesion, proliferation, and alkaline phosphatase activity of rat bone mesenchymal stem cells on LPCs significantly increased with LC content increasing in vitro. Furthermore, the evaluations of animal experiments (micro-CT, histology, and pushout load) revealed that compared with LPC20 and PI, LPC40 significantly enhanced osteogenesis and osseointegration in vivo. DISCUSSION: Incorporation of LC into PI obviously improved not only surface physicochemical properties but also biological properties of LPCs. LPC40 with high LC content displayed good biocompatibility and bioactivity, which markedly promoted osteogenesis and osseointegration. Therefore, with its superior biocompatibility and bioactivity, LPC40 could be an alternative candidate as an implant for orthopedic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.