Evidence map›Paper›PMID 33262512›Full record

ArticleGene therapy2023

Host antibacterial defense of 6-10 Gy γ-irradiated mice subjected to lentiviral vector-based Gas5 gene therapy.

Ichiaki Ito, Bradford D Loucas, Sumihiro Suzuki, Makiko Kobayashi, Fujio Suzuki

Abstract read
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In one paragraph

Article in Gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ichiaki ItoDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, TX, USA.
Bradford D LoucasDepartment of Radiation Oncology, The University of Texas Medical Branch, Galveston, TX, USA.
Sumihiro SuzukiDepartment of Biostatistics and Epidemiology, University of North Texas Health Science Center, Fort Worth, TX, USA.
Makiko KobayashiDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, TX, USA.
Fujio SuzukiDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, TX, USA. fsuzuki@utmb.edu.
The University of Texas Medical Branch at Galveston · USUniversity of North Texas Health Science Center · US

Funding

CCL1 gene therapy to inhibit bacterial translocation in acute radiation syndromesU01AI107355 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUZUKI, FUJIO · 2013 to 2017
$2.6M
NIAID NIH HHS U01 AI107355
6 · The paper itself

Abstract

Gut bacteria-associated sepsis is a serious concern in patients with gastrointestinal acute radiation syndrome (GIARS). In our previous studies, all mice exposed to 8 Gy of whole body γ-irradiation (8 Gy GIARS-mice) died by sepsis stemming from bacterial translocation. M1Mϕ located in the bacterial translocation site (i.e., the mesenteric lymph nodes, MLNs) have been characterized as major antibacterial effector cells. However, M2bMϕ, inhibitor cells for M1Mϕ polarization, predominated in the MLNs of these mice. The reduced expression of long noncoding RNA Gas5 was associated with M2bMϕ polarization. In this study, we tried to reduce the mortality rate of 8 Gy GIARS-mice through Gas5 gene transduction using lentivirus (Gas5 lentivirus). After Gas5 lentivirus injection, Gas5 RNA was overexpressed in MLN-F4/80

Indexed as

SepsisAnimalsAnti-Bacterial AgentsGenetic TherapyMiceAnti-Bacterial Agents

Identifiers

PMID33262512
OpenAlexW3108600025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.