Evidence map›Paper›PMID 33262355›Full record

ArticleScientific reports2020

Exposure to acute normobaric hypoxia results in adaptions of both the macro- and microcirculatory system.

Moritz Mirna, Nana-Yaw Bimpong-Buta, Fabian Hoffmann, Thaer Abusamrah, Thorben Knost, Oliver Sander, Yayu Monica Hew, Michael Lichtenauer, Johanna M Muessig, Raphael Romano Bruno and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Moritz MirnaDivision of Cardiology, Department of Internal Medicine II, Paracelsus Medical University of Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, Austria.ORCID 0000-0001-5679-4872
Nana-Yaw Bimpong-ButaDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Fabian HoffmannGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.
Thaer AbusamrahDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Thorben KnostDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Oliver SanderDepartment of Rheumatology, Hiller Research Institute for Rheumatology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Yayu Monica HewDepartment of Aeronautics and Astronautics, Stanford University, Stanford, CA, 94305, USA.
Michael LichtenauerDivision of Cardiology, Department of Internal Medicine II, Paracelsus Medical University of Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, Austria.
Johanna M MuessigDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Raphael Romano BrunoDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Malte KelmDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Jochen ZangeGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.
Jilada WilhelmGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.
Ulrich LimperGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.
Jens JordanGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.
Jens TankGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.
Christian JungDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany. christian.jung@med.uni-duesseldorf.de.
Heinrich Heine University Düsseldorf · DEDeutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) · DEUniversity of Salzburg · ATUniversity of Cologne · DEVaughn College of Aeronautics and Technology · USWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although acute hypoxia is of utmost pathophysiologic relevance in health and disease, studies on its effects on both the macro- and microcirculation are scarce. Herein, we provide a comprehensive analysis of the effects of acute normobaric hypoxia on human macro- and microcirculation. 20 healthy participants were enrolled in this study. Hypoxia was induced in a normobaric hypoxia chamber by decreasing the partial pressure of oxygen in inhaled air stepwisely (pO

Indexed as

Adaptation, PhysiologicalMicrocirculationAdultAltitudeBlood PressureFemaleHeart RateHemoglobinsHumansHypoxiaMalePerfusionStroke VolumeSystoleVascular ResistanceHemoglobins

Identifiers

PMID33262355
PMCPMC7708486
OpenAlexW3110455434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.