ArticleNature communications2020
Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Reduced inhibition of hippocampal adult-born granule cells by parvalbumin interneurons after TBI.bioRxiv : the preprint server for biology · 2026Article
- Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- NGF-Hydrogel Ameliorates Aberrant Adult Hippocampal Neurogenesis and Improves Hippocampal Remodeling After Epilepsy.Current issues in molecular biology · 2026Article
- Putative long range mossy fiber sprouting and regional cytochrome c oxidase alteration in the hippocampus of patients with mesial temporal lobe epilepsy.Scientific reports · 2026Article
- TRPM7 contributes to pyroptosis and its involvement in status epilepticus.Journal of neuroinflammation · 2024Article
- Inhibitory plasticity supports replay generalization in the hippocampus.Nature neuroscience · 2024Article
- Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy.Biomarker research · 2024Article
- Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus.Annual review of neuroscience · 2024Review
- Multiphoton imaging of hippocampal neural circuits: techniques and biological insights into region-, cell-type-, and pathway-specific functions.Neurophotonics · 2024Review
- Canonical Wnt activator Chir99021 prevents epileptogenesis in the intrahippocampal kainate mouse model of temporal lobe epilepsy.Experimental neurology · 2024Article
- Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence.International journal of molecular sciences · 2024Review
- Seizure event detection using intravital two-photon calcium imaging data.Neurophotonics · 2024Article
- Epilepsy insights revealed by intravital functional optical imaging.Frontiers in neurology · 2024Review
- Retinoic acid modulation of granule cell activity and spatial discrimination in the adult hippocampus.Frontiers in cellular neuroscience · 2024Article
- Seizure Event Detection Using Intravital Two-Photon Calcium Imaging Data.bioRxiv : the preprint server for biology · 2023Article
- From single-neuron dynamics to higher-order circuit motifs in control and pathological brain networks.The Journal of physiology · 2023Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Neural learning rules for generating flexible predictions and computing the successor representation.eLife · 2023Article
- Seizure-induced hilar ectopic granule cells in the adult dentate gyrus.Frontiers in neuroscience · 2023Review
- Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Temporal lobe epilepsy (TLE) is characterized by recurrent seizures driven by synchronous neuronal activity. The reorganization of the dentate gyrus (DG) in TLE may create pathological conduction pathways for synchronous discharges in the temporal lobe, though critical microcircuit-level detail is missing from this pathophysiological intuition. In particular, the relative contribution of adult-born (abGC) and mature (mGC) granule cells to epileptiform network events remains unknown. We assess dynamics of abGCs and mGCs during interictal epileptiform discharges (IEDs) in mice with TLE as well as sharp-wave ripples (SPW-Rs) in healthy mice, and find that abGCs and mGCs are desynchronized and differentially recruited by IEDs compared to SPW-Rs. We introduce a neural topic model to explain these observations, and find that epileptic DG networks organize into disjoint, cell-type specific pathological ensembles in which abGCs play an outsized role. Our results characterize identified GC subpopulation dynamics in TLE, and reveal a specific contribution of abGCs to IEDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.