ArticleNature communications2020
Ultrasensitive antibody-aptamer plasmonic biosensor for malaria biomarker detection in whole blood.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 137 citations in OpenAlex.
- Peptide-Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives.ChemMedChem · 2026Review
- Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Innovations in Aptamer Technology: SELEX To Intelligent Molecular Engineering and Clinical Translation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Mismatch-Tuned Plasmonic Nanogap Networks on Block Copolymers for Ultrasensitive Nucleic Acid Quantification.ACS nanoscience Au · 2026Article
- Direct imaging-based gradient metasurface sensor enabling spectrometer-free ultrasensitive biomolecule detection.Nature communications · 2026Article
- DNA-hybridization on gold nanospheres: a dual-fluorescence investigation of surface loading and strand length effects.Journal of biomedical optics · 2026Article
- Extreme sensitivity label-free biosensing platform based on topologically disruptive phase nano-optics.Microsystems & nanoengineering · 2026Article
- Enhanced biosensing of diabetes biomarkers by using rationally engineered carbon dots.RSC advances · 2026Review
- Antibody-aptamer Complementation: Advancing Biosensing for Disease Monitoring.Current topics in medicinal chemistry · 2026Review
- Photoinduced Immobilization on Two-Dimensional Nano Borophene Spatially Orients Capture Antibody for Highly Sensitive Biological Interactions.ACS central science · 2025Article
- Point-of-care biosensors for infectious disease diagnosis: recent updates and prospects.RSC advances · 2025Review
- Transformative biomedical devices to overcome biomatrix effects.Biosensors & bioelectronics · 2025Review
- Aptamers as innovative tools for malaria diagnosis and treatment: advances and future perspectives.Biology methods & protocols · 2025Review
- Towards Point-of-Care Single Biomolecule Detection Using Next Generation Portable Nanoplasmonic Biosensors: A Review.Biosensors · 2024Review
- Atomically dispersed recognition unit for selective in vivo photoelectrochemical medicine detection.Nature communications · 2024Article
- Self-Confined Dewetting Mechanism in Wafer-Scale Patterning of Gold Nanoparticle Arrays with Strong Surface Lattice Resonance for Plasmonic Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Highly Sensitive Labeling, Clickable Functionalization, and Glycoengineering of the MUC1 Neighboring System.JACS Au · 2024Article
- Recent Advances in Metallic Nanostructures-assisted Biosensors for Medical Diagnosis and Therapy.Current topics in medicinal chemistry · 2024Review
- A bimolecular modification strategy for developing long-lasting bone anabolic aptamer.Molecular therapy. Nucleic acids · 2023Article
- Magnetoplasmonic gold nanorods for the sensitive and label-free detection of glutathione.Nanoscale advances · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of plasmonic biosensors combining reliability and ease of use is still a challenge. Gold nanoparticle arrays made by block copolymer micelle nanolithography (BCMN) stand out for their scalability, cost-effectiveness and tunable plasmonic properties, making them ideal substrates for fluorescence enhancement. Here, we describe a plasmon-enhanced fluorescence immunosensor for the specific and ultrasensitive detection of Plasmodium falciparum lactate dehydrogenase (PfLDH)-a malaria marker-in whole blood. Analyte recognition is realized by oriented antibodies immobilized in a close-packed configuration via the photochemical immobilization technique (PIT), with a top bioreceptor of nucleic acid aptamers recognizing a different surface of PfLDH in a sandwich conformation. The combination of BCMN and PIT enabled maximum control over the nanoparticle size and lattice constant as well as the distance of the fluorophore from the sensing surface. The device achieved a limit of detection smaller than 1 pg/mL (<30 fM) with very high specificity without any sample pretreatment. This limit of detection is several orders of magnitude lower than that found in malaria rapid diagnostic tests or even commercial ELISA kits. Thanks to its overall dimensions, ease of use and high-throughput analysis, the device can be used as a substrate in automated multi-well plate readers and improve the efficiency of conventional fluorescence immunoassays.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.