Evidence map›Paper›PMID 33262310›Full record

ArticleJournal of cell science2021

UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II.

Juri Habicht, Ashley Mooneyham, Asumi Hoshino, Mihir Shetty, Xiaonan Zhang, Edith Emmings, Qing Yang, Courtney Coombes, Melissa K Gardner, Martina Bazzaro

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Juri HabichtBradenburg Medical School - Theodor Fontane, Neuruppin 16816, Germany.
Ashley MooneyhamMasonic Cancer Center and Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8526-1933
Asumi HoshinoMasonic Cancer Center and Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, USA.
Mihir ShettyMasonic Cancer Center and Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, USA.
Xiaonan ZhangBradenburg Medical School - Theodor Fontane, Neuruppin 16816, Germany.
Edith EmmingsBradenburg Medical School - Theodor Fontane, Neuruppin 16816, Germany.ORCID 0000-0002-5816-3510
Qing YangDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Courtney CoombesDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2159-3103
Melissa K GardnerDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Martina BazzaroMasonic Cancer Center and Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, USA mbazzaro@umn.edu.ORCID 0000-0002-9426-9515
University of Minnesota · USMedizinische Hochschule Brandenburg Theodor Fontane · DE

Funding

Gardner Lab MIRA Proposal: Microtubules and MitosisR35GM126974 · NIGMS · UNIVERSITY OF MINNESOTA · PI Melissa Gardner · 2018 to 2026
$3.4M
Investigation of the role of UNC-45A in Paclitaxel-mediated microtubule stabilityR01GM130800 · NIGMS · UNIVERSITY OF MINNESOTA · PI BAZZARO, MARTINA · 2019 to 2020
$614k
NIGMS NIH HHS R01 GM130800NIGMS NIH HHS R35 GM126974
6 · The paper itself

Abstract

In invertebrates, UNC-45 regulates myosin stability and functions. Vertebrates have two distinct isoforms of the protein: UNC-45B, expressed in muscle cells only, and UNC-45A, expressed in all cells and implicated in regulating both non-muscle myosin II (NMII)- and microtubule (MT)-associated functions. Here, we show that,

Indexed as

Intracellular Signaling Peptides and ProteinsMicrotubulesAnimalsHumansMolecular ChaperonesMyosinsMyosin Type IIRatsIntracellular Signaling Peptides and ProteinsMolecular ChaperonesMyosinsMyosin Type IIUNC45A protein, humanMicrotubule-destabilizing proteinsMicrotubule latticeMicrotubulesTauUNC-45A

Identifiers

PMID33262310
PMCPMC7803465
OpenAlexW3107501012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.