Trial reportProceedings of the National Academy of Sciences of the United States of America2020
The Fast Track intervention's impact on behaviors of despair in adolescence and young adulthood.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01653535 (Multisite Prevention of Conduct Problems), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multisite Prevention of Conduct Problems
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- The randomized controlled trial Fast Track multilevel intervention for children with early-emerging conduct problems breaks intergenerational transmission of violence across three generations.Journal of child psychology and psychiatry, and allied disciplines · 2026Trial
- Fast Track Intervention Effects and Mechanisms of Action Through Established Adulthood.Prevention science : the official journal of the Society for Prevention Research · 2025Trial
- Targeted Child Mental Health Prevention and Parenting Support Within a Canadian Context: A Randomized Controlled Trial Evaluating the U.S.-Developed Family Check-Up®.Prevention science : the official journal of the Society for Prevention Research · 2025Trial
- Intergenerational Effects of the Fast Track Intervention on Next-Generation Child Outcomes: A Preregistered Randomized Clinical Trial.The American journal of psychiatry · 2024Trial
- Fast Track intervention effects on family formation.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2023Trial
- Annual Research Review: Beyond the target - understanding crossover effects in family-centered prevention.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Childhood conduct problems, potential snares in adolescence, and problematic substance use in Brazil.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025Article
- Pathways of intergenerational transmission of depression: The role of the Fast Track intervention.Development and psychopathology · 2025Article
- A scoping review of interventions addressing social determinants of health and their influence on opioid use disorder outcomes.Drug and alcohol dependence · 2025Article
- Parental Diseases of Despair and Suicidal Events in Their Children.JAMA network open · 2025Article
- Impulsivity profiles across five harmonized longitudinal childhood preventive interventions and associations with adult outcomes.Development and psychopathology · 2025Article
- The Role of Despair in Predicting Self-Destructive Behaviors.Population research and policy review · 2025Article
- Adolescents with Elevated Psychopathic Traits are Associated with an Increased Risk for Premature Mortality.Research on child and adolescent psychopathology · 2025Article
- Taking John Schulenberg's "long view" on successful transitions to adulthood: Associations with adult substance use.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2024Article
- Transformational narrative changes as a community-level approach to the prevention of adverse childhood experiences and substance use.American journal of community psychology · 2024Article
- Annual Research Review: Sex, gender, and internalizing conditions among adolescents in the 21st century - trends, causes, consequences.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Reducing Suicidal Ideation in Preadolescents With a History of Foster Care by Promoting School Readiness in Early Childhood.Child maltreatment · 2024Article
- Psychosis Symptom Trajectories Across Childhood and Adolescence in Three Longitudinal Studies: An Integrative Data Analysis with Mixture Modeling.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- Substance Use Outcomes from Two Formats of a Cognitive-Behavioral Intervention for Aggressive Children: Moderating Roles of Inhibitory Control and Intervention Engagement.Brain sciences · 2021Article
- Perceptions of Diseases of Despair by Members of Rural and Urban High-Prevalence Communities: A Qualitative Study.JAMA network open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
How to mitigate the dramatic increase in the number of self-inflicted deaths from suicide, alcohol-related liver disease, and drug overdose among young adults has become a critical public health question. A promising area of study looks at interventions designed to address risk factors for the behaviors that precede these -often denoted-"deaths of despair." This paper examines whether a childhood intervention can have persistent positive effects by reducing adolescent and young adulthood (age 25) behaviors that precede these deaths, including suicidal ideation, suicide attempts, hazardous drinking, and opioid use. These analyses test the impact and mechanisms of action of Fast Track (FT), a comprehensive childhood intervention designed to decrease aggression and delinquency in at-risk kindergarteners. We find that random assignment to FT significantly decreases the probability of exhibiting any behavior of despair in adolescence and young adulthood. In addition, the intervention decreases the probability of suicidal ideation and hazardous drinking in adolescence and young adulthood as well as opioid use in young adulthood. Additional analyses indicate that FT's improvements to children's interpersonal (e.g., prosocial behavior, authority acceptance), intrapersonal (e.g., emotional recognition and regulation, social problem solving), and academic skills in elementary and middle school partially mediate the intervention effect on adolescent and young adult behaviors of despair and self-destruction. FT's improvements to interpersonal skills emerge as the strongest indirect pathway to reduce these harmful behaviors. This study provides evidence that childhood interventions designed to improve these skills can decrease the behaviors associated with premature mortality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.