Evidence map›Paper›PMID 33262259›Full record

ArticlemBio2020

Role of Glutathione in Buffering Excess Intracellular Copper in

Louisa J Stewart, Cheryl-Lynn Y Ong, May M Zhang, Stephan Brouwer, Liam McIntyre, Mark R Davies, Mark J Walker, Alastair G McEwan, Kevin J Waldron, Karrera Y Djoko

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Bacteria Under Metal Stress-Molecular Mechanisms of Metal Tolerance.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Louisa J Stewart *Department of Biosciences, Durham University, Durham, United Kingdom.
Cheryl-Lynn Y Ong *School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Australia.ORCID 0000-0001-6036-6889
May M ZhangSchool of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Australia.
Stephan BrouwerSchool of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Australia.
Liam McIntyreDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Mark R DaviesDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-6141-5179
Mark J WalkerSchool of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Australia.ORCID 0000-0001-7423-2769
Alastair G McEwanSchool of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, Australia.ORCID 0000-0002-2419-1003
Kevin J WaldronBiosciences Institute, Faculty of Medical Sciences, Framlington Place, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0002-5577-7357
Karrera Y DjokoDepartment of Biosciences, Durham University, Durham, United Kingdom karrera.djoko@durham.ac.uk.ORCID 0000-0001-9814-6515
The University of Queensland · AUDurham University · GBThe University of Melbourne · AUNewcastle University · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S006818/1Wellcome TrustWellcome Trust 214930/Z/18/Z
6 · The paper itself

Abstract

Copper (Cu) is an essential metal for bacterial physiology but in excess it is bacteriotoxic. To limit Cu levels in the cytoplasm, most bacteria possess a transcriptionally responsive system for Cu export. In the Gram-positive human pathogen

Indexed as

AnimalsBacterial ProteinsBiofilmsBiological TransportCopperCytoplasmDisease Models, AnimalEnergy MetabolismGene Expression Regulation, BacterialGlutathioneHomeostasisMiceMutationStreptococcal InfectionsStreptococcus pyogenesStress, PhysiologicalBacterial ProteinsCopA protein, BacteriaCopperGlutathionecopper exportcopper homeostasiscopper stresscopper toleranceglutathionegroup A Streptococcusmetal buffer

Identifiers

PMID33262259
PMCPMC7733945
OpenAlexW3109532390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.