ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Perinatal hardship and infant neurodevelopment: insights from a global pandemic.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
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- Gendering the Menstrual Cycle in Behavioral Neuroendocrinology.American journal of human biology : the official journal of the Human Biology Council · 2026Review
- Effects of psychosocial stress on laryngeal microbiology and epithelial barrier integrity.Scientific reports · 2025Article
- Paternal morphine alters offspring circulating beta-endorphin and corticosterone responses to oxycodone and cocaine.Neuropharmacology · 2025Article
- Chronic corticosterone administration alters synaptic mitochondrial function within the hippocampus of C57Bl/6NTac mice.Physiology & behavior · 2024Article
- Enriched housing differentially alters allostatic load and cardiopulmonary responses to wildfire-related smoke in male and female mice.Journal of toxicology and environmental health. Part A · 2024Article
- Repeated exposure to multiple concurrent stressors alters visual processing in the adult posterior parietal cortex.Neurobiology of stress · 2024Article
- Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders.Molecular biology reports · 2024Review
- Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus.Metabolic brain disease · 2024Article
- Developmental and adult stress: effects of steroids and neurosteroids.Stress (Amsterdam, Netherlands) · 2024Review
- Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders.BMC neuroscience · 2023Review
- Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function.iScience · 2023Article
- Estrogen receptor beta in the central amygdala regulates the deleterious behavioral and neuronal consequences of repeated social stress in female rats.Neurobiology of stress · 2023Article
- Steroid Hormone Interaction with Dendritic Spines: Implications for Neuropsychiatric Disease.Advances in neurobiology · 2023Review
- Single-Cell Transcriptional Changes in Hypothalamic Corticotropin-Releasing Factor-Expressing Neurons After Early-Life Adversity Inform Enduring Alterations in Vulnerabilities to Stress.Biological psychiatry global open science · 2023Article
- Temporal endurance of exercise-induced benefits on hippocampus-dependent memory and synaptic plasticity in female mice.Neurobiology of learning and memory · 2022Article
- Sex differences in cognition following variations in endocrine status.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Review
- Review
- Sex-dependent effects of multiple acute concurrent stresses on memory: a role for hippocampal estrogens.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Stress may promote emotional and cognitive disturbances, which differ by sex. Adverse outcomes, including memory disturbances, are typically observed following chronic stress, but are now being recognized also after short events, including mass shootings, assault, or natural disasters, events that consist of concurrent multiple acute stresses (MAS). Prior work has established profound and enduring effects of MAS on memory in males. Here we examined the effects of MAS on female mice and probed the role of hormonal fluctuations during the estrous cycle on MAS-induced memory problems and the underlying brain network and cellular mechanisms. Female mice were impacted by MAS in an estrous cycle-dependent manner: MAS impaired hippocampus-dependent spatial memory in early-proestrous mice, characterized by high levels of estradiol, whereas memory of mice stressed during estrus (low estradiol) was spared. As spatial memory requires an intact dorsal hippocampal CA1, we examined synaptic integrity in mice stressed at different cycle phases and found a congruence of dendritic spine density and spatial memory deficits, with reduced spine density only in mice stressed during high estradiol cycle phases. Assessing MAS-induced activation of brain networks interconnected with hippocampus, we identified differential estrous cycle-dependent activation of memory- and stress-related regions, including the amygdala. Network analyses of the cross-correlation of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.