Evidence map›Paper›PMID 33262183›Full record

ArticleCancer discovery2020

Histone H3 G34 Tail Mutations in Cancer: Actions in

Jonathan D Licht

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cancer discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Jonathan D LichtUniversity of Florida, Gainesville, Florida. jdlicht@ufl.edu.ORCID https://orcid.org/0000-0002-3942-1369

Funding

Spatio-Temporal Organization of Chromatin and Information Transfer in CancerU54CA193419 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LICHT, JONATHAN D., O'HALLORAN, THOMAS V · 2015 to 2020
$10.4M
NCI NIH HHS U54 CA193419
6 · The paper itself

Abstract

Sequencing of cancer genomes has demonstrated that driver mutations occur in every component of the transcriptional machinery including histones that comprise the nucleosome. Histone mutations may affect the "tail" residues subject to post-translational modification and can compromise the structural integrity of the histone octamer.

Indexed as

Giant Cell Tumor of BoneHistonesCell DifferentiationChromatinGene ExpressionHumansMutationNucleosomesOsteoblastsChromatinHistonesNucleosomes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.