Evidence map›Paper›PMID 33262172›Full record

ArticleRespiratory care2021

Elastic Power of Mechanical Ventilation in Morbid Obesity and Severe Hypoxemia.

Muhammad K Hayat Syed, John Selickman, Michael D Evans, David Dries, John J Marini

Open access · bronzeAbstract read
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Article in Respiratory care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Muhammad K Hayat SyedPulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota.
John SelickmanDepartment of Medicine, Regions Hospital, Saint Paul, Minnesota.
Michael D EvansClinical and Translational Science Institute, University of Minnesota, Minneapolis, Minnesota.
David DriesDepartment of Surgery, Regions Hospital, Saint Paul, Minnesota.
John J MariniPulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota. marin002@umn.edu.
Regions Hospital · USUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1 TR002494
6 · The paper itself

Abstract

backgroundTo minimize ventilator-induced lung injury, the primary clinical focus is currently expanding from measuring static indices of the individual tidal cycle (eg, plateau pressure and tidal volume) to more inclusive indicators of energy load, such as total power and its elastic components. Morbid obesity may influence these components. We characterized the relative values of elastic subcomponents of total power (ie, driving power and dynamic power) in subjects with severe hypoxemia, morbid obesity, or their combination.

methodsWe analyzed data from subjects receiving mechanical ventilation divided into 4 groups. [Formula: see text]/[Formula: see text] < 150 mm Hg (severe hypoxemia) indicated probable reduction of lung compliance while body mass index > 40 kg/m

resultsGroups 1-4 included 61, 52, 49, and 51 subjects, respectively. Mean body mass index averaged 28.7 kg/m

conclusionsIn mechanically ventilated subjects, stress and energy-based ventilator-induced lung injury indicators are influenced by the relative contributions of chest wall and lung to overall respiratory mechanics. Numerical guidelines for ventilator-induced lung injury risk must strongly consider adjustment for these elastic characteristics in morbid obesity.

Indexed as

Obesity, MorbidRespiratory Distress SyndromeVentilator-Induced Lung InjuryHumansHypoxiaRespiration, ArtificialTidal VolumeARDSelastic power of ventilationhypoxemiamechanical ventilationmorbid obesityrespiratory complianceventilator-induced lung injury

Identifiers

PMID33262172
PMCPMC8651184
OpenAlexW3110233369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.