Evidence map›Paper›PMID 33262142›Full record

ArticleGenes & development2020

A window in time for β-cell regeneration.

Benjamin J Weidemann, Joseph Bass

Abstract readComment
In one paragraph

Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Benjamin J WeidemannDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Joseph BassDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Funding

SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI ZEE, PHYLLIS C. · 1994 to 2021
$31.5M
TRANSGENIC COREP60DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI BELL, GRAEME I · 1985 to 2012
$25.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9M
Integration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9M
Bioenergetic Mechanisms Underlying Circadian Dietary InterventionR01AG065988 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2019 to 2023
$2.0M
The Circadian System as a Neuronal Regulator of Feeding Time and Body Weight SetpointR01DK113011 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2018 to 2021
$1.7M
Genomic Basis for the Circadian Regulation of B-cell Function and Glucose HomeostasisF30DK116481 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WEIDEMANN, BENJAMIN JOHN · 2017 to 2021
$190k
NIA NIH HHS P01 AG011412NIA NIH HHS R01 AG065988NIDDK NIH HHS F30 DK116481NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P60 DK020595NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK113011
6 · The paper itself

Abstract

In vivo regeneration of β cells provides hope for self-renewal of functional insulin-secreting cells following β-cell failure, a historically fatal condition now sustainable only by administration of exogenous insulin. Despite advances in the treatment of diabetes mellitus, the path toward endogenous renewal of β-cell populations has remained elusive. Intensive efforts have focused on elucidating pancreatic transcriptional programs that can drive the division and (

Indexed as

Circadian ClocksDiabetes MellitusInsulin-Secreting CellsHumansInsulinPancreasInsulincircadian clockworkdiabetesglucose metabolismInsulin-rtTA/TET-DTA mouse modelpancreatic α and β cellsβ-cell proliferationβ-cell regeneration

Identifiers

PMID33262142
PMCPMC7706709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.