SynthesisParasitology2021
Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses.
Synthesis in Parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses.Parasitology · 2021Pooled it
- Systematic review of modifiable risk factors shows little evidential support for most current practices in Cryptosporidium management in bovine calves.Parasitology research · 2020Pooled it
- Paromomycin improves clinical outcomes and growth performance compared with halofuginone in dairy calves naturally exposed toVeterinary and animal science · 2026Article
- Cryptosporidium parvum and bovine coronavirus in naturally and experimentally exposed calves: clinical outcome and pathogen shedding.Veterinary research · 2026Article
- Influence ofFrontiers in veterinary science · 2026Article
- Importance and Characterisation of Concurrent Pathogens in Diarrhoeic Calves from North-Western Spain.Animals : an open access journal from MDPI · 2025Article
- Prenatal Factors Influencing Calf Morbidity and Mortality in Dairy Cattle: A Systematic Review of the Literature (2000-2024).Animals : an open access journal from MDPI · 2025Review
- Gut Barrier Dysfunction and Microbiota Variations in Cryptosporidiosis: A Comprehensive Review.Veterinary sciences · 2025Review
- The Evaluation of the Efficacy of a Novel Subunit Vaccine in the Prevention ofAnimals : an open access journal from MDPI · 2025Article
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- Article
- Apical-out bovine intestinal organoids as an infection model forCurrent research in parasitology & vector-borne diseases · 2025Article
- Abomasitis associated with halofuginone intoxication in pre-weaned calves.BMC veterinary research · 2024Article
- Understanding theFrontiers in parasitology · 2024Review
- Article
- Medical prospects of cryptosporidiosisVeterinary world · 2024Article
- Specific pathway abundances in the neonatal calf faecal microbiome are associated with susceptibility to Cryptosporidium parvum infection: a metagenomic analysis.Animal microbiome · 2023Article
- Host innate immune responses and microbiome profile of neonatal calves challenged withFrontiers in cellular and infection microbiology · 2023Article
- Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: A comprehensive review.Frontiers in cellular and infection microbiology · 2023Review
- Cryptosporidiosis: From Prevention to Treatment, a Narrative Review.Microorganisms · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for the treatment of calves with HFG. Evaluated outcomes were oocyst shedding, diarrhoea, mortality and weight gain. Experiments had to describe results for same age animals in contemporary arms. Most doses were 100-150 mcg kg-1 day-1. Results were subgrouped by study design, experiments with the lowest risk of bias and lack of industry funding. Eighteen articles were found that described 25 experiments. Most evidence came from randomized controlled trials in Europe. Significantly lower incidence of oocyst shedding, diarrhoea burden and mortality was reported when treatment started before calves were 5 days old. Most studies reported on outcomes for animals up to at least 28 days old. Publication bias was possible in all outcomes and seemed especially likely for diarrhoea outcomes. Beneficial results when HFG treatment was initiated in calves older than 5 days were also found. Prophylactic treatment to prevent cryptosporidiosis is effective in preventing multiple negative outcomes and is beneficial to calf health and will result in a reduction of environmental contamination by Cryptosporidium oocysts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.