ArticleBMC infectious diseases2020
Characterization of the virulence of Pseudomonas aeruginosa strains causing ventilator-associated pneumonia.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
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42 citing papers in PubMed, 84 citations in OpenAlex.
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- Exploring the occurrence of Pseudomonas aeruginosa and comprehensive whole genome analysis of the bcsir_p4_s20 strain from municipal wastewater in Chattogram.World journal of microbiology & biotechnology · 2025Article
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- Virulence factors of Pseudomonas aeruginosa and immune response during exacerbations and stable phase in bronchiectasis.Scientific reports · 2025Article
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- The efficacy and safety of ceftazidime/avibactam or polymyxin B based regimens forFrontiers in pharmacology · 2025Article
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- The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.PLOS global public health · 2025Article
- Comparative proteomic analysis to annotate the structural association of the hypothetical proteins from the conserved domain of P. aeruginosa as novel vaccine candidates.Biotechnology letters · 2024Article
- Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains.Computational and structural biotechnology journal · 2024Article
- Does Every Strain ofPathogens (Basel, Switzerland) · 2024Article
- Biofilm Production in Intensive Care Units: Challenges and Implications.Pathogens (Basel, Switzerland) · 2024Review
- The Biofilm Inhibition Properties of Glucosamine Gold Nanoparticles in Combination with Meropenem againstMaterials (Basel, Switzerland) · 2024Article
- Unraveling the Complex Interactions: Machine Learning Approaches to Predict Bacterial Survival against ZnO and Lanthanum-Doped ZnO Nanoparticles.Antibiotics (Basel, Switzerland) · 2024Article
- A paper biosensor for overcoming matrix effects interfering with the detection of sputum pyocyanin with competitive immunoassays.Mikrochimica acta · 2023Article
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- Prevalence of different virulence factors and their association with antimicrobial resistance among Pseudomonas aeruginosa clinical isolates from Egypt.BMC microbiology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe objective of this study was to evaluate the virulence of P. aeruginosa ventilator-associated pneumonia (VAP) strains (cases) in terms of biofilm production and other phenotypic and genotypic virulence factors compared to P. aeruginosa strains isolated from other infections (controls).
methodsBiofilm production was tested to assess biomass production and metabolic activity using crystal violet binding assay and XTT assay, respectively. Pigment production (pyocyanin and pyoverdine) was evaluated using cetrimide agar. Virulence genes were detected by conventional multiplex PCR and virulence was tested in an in vivo model in Galleria mellonella larvae.
resultsWe did not find statistically significant differences between VAP and no-VAP strains (p > 0.05) regarding biofilm production. VAP strains had no production of pyocyanin after 24 h of incubation (p = 0.023). The distribution of virulence genes between both groups were similar (p > 0.05). VAP strains were less virulent than non-VAP strains in an in vivo model of G. mellonella (p < 0.001).
conclusionThe virulence of VAP-Pseudomonas aeruginosa does not depend on biofilm formation, production of pyoverdine or the presence of some virulence genes compared to P. aeruginosa isolated from non-invasive locations. However, VAP strains showed attenuated virulence compared to non-VAP strains in an in vivo model of G. mellonella.
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