Observational studyBMC infectious diseases2020
The clinical characteristics and outcome of cryptococcal meningitis with AIDS in a tertiary hospital in China: an observational cohort study.
Observational study in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Trends and Clinical Characteristics of HIV and Cerebrovascular Disease in Low- and Middle-Income Countries (LMICs) Between 1990 and 2021.Current HIV/AIDS reports · 2022Pooled it
- Transverse Comparison of Clinical Characteristics and Prognostic Factors in HIV-Infected Patients with Cytomegalovirus Encephalitis in Guangdong, China.Current HIV research · 2026Article
- Ophthalmoplegia as a Rare Initial Presentation of Cryptococcal Meningitis: A Case Report and Literature ReviewRevista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2025Review
- Article
- The clinic-based predictive modeling for prognosis of patients with cryptococcal meningitis.BMC infectious diseases · 2023Article
- Cerebral infarction in HIV-negative patients with cryptococcal meningitis: its predictors and impact on outcomes.BMC infectious diseases · 2022Article
- A nomogram for predicting paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis among HIV-infected individuals in China.AIDS research and therapy · 2022Article
- Ventriculoperitoneal shunt is associated with increased cerebrospinal fluid protein level in HIV-infected cryptococcal meningitis patients.BMC infectious diseases · 2022Article
- Analysis of the efficacy and related factors of ventriculoperitoneal shunt for AIDS with cryptococcal meningitis.Frontiers in surgery · 2022Article
- Establishment of a novel scoring model for mortality risk prediction in HIV-infected patients with cryptococcal meningitis.BMC infectious diseases · 2021Article
- The Emerging Role of Mast Cells in Response to Fungal Infection.Frontiers in immunology · 2021Review
- Pathogenic characteristics of central nervous system infections in AIDS individuals: a retrospective cohort study based on immune status.Frontiers in neurologyArticle
- Cerebrospinal fluid shunting for the management of cryptococcal meningitis: a scoping review.Therapeutic advances in infectious diseaseArticle
- Longitudinally Extensive Transverse Myelitis and Vasculitis by Cryptococcosis in a Non-HIV Patient: A Case Report.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDespite the profound impact of antiretroviral therapy in the control of AIDS mortality, central nervous system opportunistic infections remains a significant burden in AIDS patients. This retrospective study aims to elucidate the clinical characteristics, outcome and risk factors of cryptococcal meningitis (CM) poor prognosis in AIDS patients from a tertiary hospital in China.
methodsClinical data from 128 patients admitted in Beijing Ditan Hospital, Capital Medical University from November 2008 to November 2017 was collected. The cohort was stratified based on treatment outcome (effective 79%, and ineffective 21%), and Multivariate Logistic regression analysis used to identify risk factors of poor disease prognosis.
resultsAge, incidence of cerebral infarction, the proportion of consciousness disorder, and fasting plasma glucose was higher in the ineffective treatment group than the effective treatment group. The duration of treatment in the induction period of the ineffective group was significantly shorter than that of the effective group. Multivariate Logistic regression analysis indicated that the occurrence of cerebral hernia and consciousness disorder were risk factors for the prognosis of AIDS patients with CM infection, while the duration of treatment in the induction period was a indicative of a better prognosis in AIDS with CM infection complications. Finally, shunt decompression therapy correlated with a better disease outcome.
conclusionsThis retrospective study exposes the main risk factors associated with worse disease prognosis in AIDS patients with CM infection complications.
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