Evidence map›Paper›PMID 33261176›Full record

ArticleGenes2020

A

Anna Letko, Katie M Minor, Steven G Friedenberg, G Diane Shelton, Jill Pesayco Salvador, Paul J J Mandigers, Peter A J Leegwater, Paige A Winkler, Simon M Petersen-Jones, Bryden J Stanley and 6 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Whole exome sequencing as a screening tool in dogs: A pilot study.Computational and structural biotechnology journal · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Anna LetkoInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Katie M MinorDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Steven G FriedenbergDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
G Diane SheltonDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA 92093-0709, USA.
Jill Pesayco SalvadorDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA 92093-0709, USA.
Paul J J MandigersDepartment of Clinical Sciences, Utrecht University, 3584 CM Utrecht, The Netherlands.
Peter A J LeegwaterDepartment of Clinical Sciences, Utrecht University, 3584 CM Utrecht, The Netherlands.
Paige A WinklerDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Simon M Petersen-JonesDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Bryden J StanleyDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Kari J EkenstedtDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Gary S JohnsonDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.
Liz HansenDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.
Vidhya JagannathanInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
James R MickelsonDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Cord DrögemüllerInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Michigan State University · USUniversity of Bern · CHUniversity of Minnesota · USUniversity of California San Diego · USUniversity of Missouri · USUtrecht University · NLPurdue University West Lafayette · US

Funding

Immunological Basis of Autoimmune Addison's Disease in a Novel Canine Model SystemK01OD027058 · OD · UNIVERSITY OF MINNESOTA · PI FRIEDENBERG, STEVEN GENE · 2019 to 2023
$724k
Novel Genetic Models for Vertebral AbnormalitiesK01OD027051 · OD · PURDUE UNIVERSITY · PI EKENSTEDT, KARI J · 2019 to 2023
$627k
NIH HHS K01 OD027051NIH HHS K01 OD027058
6 · The paper itself

Abstract

Laryngeal paralysis associated with a generalized polyneuropathy (LPPN) most commonly exists in geriatric dogs from a variety of large and giant breeds. The purpose of this study was to discover the underlying genetic and molecular mechanisms in a younger-onset form of this neurodegenerative disease seen in two closely related giant dog breeds, the Leonberger and Saint Bernard. Neuropathology of an affected dog from each breed showed variable nerve fiber loss and scattered inappropriately thin myelinated fibers. Using across-breed genome-wide association, haplotype analysis, and whole-genome sequencing, we identified a missense variant in the

Indexed as

Mutation, MissensePoint MutationAge of OnsetAmino Acid SubstitutionAnimalsAnimals, WildAxonsBreedingCanidaeCell Adhesion Molecules, NeuronalDog DiseasesDogsHaplotypesNerve Fibers, MyelinatedPeroneal NervePolymorphism, Single NucleotideCell Adhesion Molecules, NeuronalCanis familiariscontactinLabrador retrieverLeonbergerneurological disorderrare diseaseSaint Bernardwhole-genome sequencing

Identifiers

PMID33261176
PMCPMC7761076
OpenAlexW3110618962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.