Evidence map›Paper›PMID 33261161›Full record

ArticleMolecules (Basel, Switzerland)2020

Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency.

Kirill P Cheremnykh, Victor A Savelyev, Sergey A Borisov, Igor D Ivanov, Dmitry S Baev, Tatyana G Tolstikova, Valentin A Vavilin, Elvira E Shults

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kirill P CheremnykhNovosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Victor A SavelyevNovosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Sergey A BorisovNovosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-6415-5840
Igor D IvanovThe Federal Research Center Insitute of Molecular Biology and Biophysics, 2/12, Timakov St., 630117 Novosibirsk, Russia.
Dmitry S BaevNovosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-1795-9256
Tatyana G TolstikovaNovosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.
Valentin A VavilinThe Federal Research Center Insitute of Molecular Biology and Biophysics, 2/12, Timakov St., 630117 Novosibirsk, Russia.
Elvira E ShultsNovosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-0761-9696
Novosibirsk Institute of Organic Chemistry · RUInstitute of Molecular Biology and Biophysics · RU

Funding

Russian Science Foundation 18-13-00361
6 · The paper itself

Abstract

Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid lappaconitine and pyrimidine fragments are reported. One route takes place via first converting of lappaconitine to 1-ethynyl-lappaconitine, followed by the Sonogashira cross-coupling-cyclocondensation sequences. The other involves the palladium-catalyzed carbonylative Sonogashira reaction of 5'-iodolappaconitine with aryl acetylene and Mo (CO)

Indexed as

AconitineAnalgesicsAnimalsMaleMiceNociceptionortho-AminobenzoatesPainPyrimidinesAconitineAnalgesicsanthranilic acidlappaconitineortho-AminobenzoatesPyrimidinesalkaloidsanalgesic activitycross-coupling reactionlappaconitinemulti-component synthesispyrimidine

Identifiers

PMID33261161
PMCPMC7730767
OpenAlexW3109906232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.