Evidence map›Paper›PMID 33261049›Full record

ArticleInternational journal of molecular sciences2020

Strand Displacement Activity of PrimPol.

Elizaveta O Boldinova, Ekaterina A Belousova, Diana I Gagarinskaya, Ekaterina A Maltseva, Svetlana N Khodyreva, Olga I Lavrik, Alena V Makarova

Open access · goldAbstract read
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In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elizaveta O BoldinovaInstitute of Molecular Genetics, National Research Center "Kurchatov Institute", Kurchatov sq. 2, 123182 Moscow, Russia.
Ekaterina A BelousovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.
Diana I GagarinskayaInstitute of Molecular Genetics, National Research Center "Kurchatov Institute", Kurchatov sq. 2, 123182 Moscow, Russia.
Ekaterina A MaltsevaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.
Svetlana N KhodyrevaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.
Olga I LavrikInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russia.ORCID 0000-0001-5980-8889
Alena V MakarovaInstitute of Molecular Genetics, National Research Center "Kurchatov Institute", Kurchatov sq. 2, 123182 Moscow, Russia.ORCID 0000-0002-6513-892X
Institute of Chemical Biology and Fundamental Medicine · RUKurchatov Institute · RU

Funding

Russian scientific foundation 18-14-00354
6 · The paper itself

Abstract

Human PrimPol is a unique enzyme possessing DNA/RNA primase and DNA polymerase activities. In this work, we demonstrated that PrimPol efficiently fills a 5-nt gap and possesses the conditional strand displacement activity stimulated by Mn

Indexed as

DNADNA-Directed DNA PolymeraseDNA PrimaseFlap EndonucleasesHumansManganeseMultifunctional EnzymesNuclear ProteinsReplication Protein ARNASubstrate SpecificityDNADNA-Directed DNA PolymeraseDNA PrimaseFlap EndonucleasesManganeseMultifunctional EnzymesNuclear ProteinsPOLDIP2 protein, humanPrimPol protein, humanReplication Protein ARNAFEN1PolDIP2PrimPolRPAstrand displacement

Identifiers

PMID33261049
PMCPMC7729601
OpenAlexW3109631991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.