Evidence map›Paper›PMID 33260966›Full record

ReviewVaccines2020

Current Immunotherapy Approaches in Non-Hodgkin Lymphomas.

Robert Pytlik, Kamila Polgarova, Jana Karolova, Pavel Klener

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robert PytlikInstitute of Haematology and Blood Transfusion, 128 00 Prague, Czech Republic.
Kamila PolgarovaFirst Department of Internal Medicine-Hematology, University General Hospital in Prague and First Faculty of Medicine, Charles University, U Nemocnice 2, 128 08 Prague 2, 110 00 Prague, Czech Republic.
Jana KarolovaFirst Department of Internal Medicine-Hematology, University General Hospital in Prague and First Faculty of Medicine, Charles University, U Nemocnice 2, 128 08 Prague 2, 110 00 Prague, Czech Republic.
Pavel KlenerFirst Department of Internal Medicine-Hematology, University General Hospital in Prague and First Faculty of Medicine, Charles University, U Nemocnice 2, 128 08 Prague 2, 110 00 Prague, Czech Republic.ORCID 0000-0001-7786-9378
Charles University · CZ

Funding

Agentura Pro Zdravotnický Výzkum České Republiky NV-19-08-00144Grantová Agentura České Republiky GA20-25308SGrantová Agentura, Univerzita Karlova GAUK-748318
6 · The paper itself

Abstract

Non-Hodgkin lymphomas (NHLs) are lymphoid malignancies of B- or T-cell origin. Despite great advances in treatment options and significant improvement of survival parameters, a large part of NHL patients either present with a chemotherapy-refractory disease or experience lymphoma relapse. Chemotherapy-based salvage therapy of relapsed/refractory NHL is, however, capable of re-inducing long-term remissions only in a minority of patients. Immunotherapy-based approaches, including bispecific antibodies, immune checkpoint inhibitors and genetically engineered T-cells carrying chimeric antigen receptors, single-agent or in combination with therapeutic monoclonal antibodies, immunomodulatory agents, chemotherapy or targeted agents demonstrated unprecedented clinical activity in heavily-pretreated patients with NHL, including chemotherapy-refractory cases with complex karyotype changes and other adverse prognostic factors. In this review, we recapitulate currently used immunotherapy modalities in NHL and discuss future perspectives of combinatorial immunotherapy strategies, including patient-tailored approaches.

Indexed as

bispecific antibodiesCAR T-cellsimmune checkpoint inhibitorsimmunomodulatory agentsnon-Hodgkin lymphomas

Identifiers

PMID33260966
PMCPMC7768428
OpenAlexW3106848797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.