Evidence map›Paper›PMID 33260954›Full record

ArticleMolecules (Basel, Switzerland)2020

Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents.

Ashraf A Aly, Stefan Bräse, Alaa A Hassan, Nasr K Mohamed, Lamiaa E Abd El-Haleem, Martin Nieger, Nesrin M Morsy, Mohammed B Alshammari, Mahmoud A A Ibrahim, Elshimaa M N Abdelhafez

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Heterocyclic Phytochemicals as Anticancer Agents.Current topics in medicinal chemistry · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Thiazole Ring-A Biologically Active Scaffold.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Ashraf A AlyDepartment of Chemistry, Faculty of Science, Minia University, El Minia 61519, Egypt.ORCID 0000-0002-0314-3408
Stefan BräseInstitute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0003-4845-3191
Alaa A HassanDepartment of Chemistry, Faculty of Science, Minia University, El Minia 61519, Egypt.
Nasr K MohamedDepartment of Chemistry, Faculty of Science, Minia University, El Minia 61519, Egypt.
Lamiaa E Abd El-HaleemInstitute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
Martin NiegerDepartment of Chemistry, University of Helsinki, P.O. Box 55 (A. I. Virtasen aukio I), 00014 Helsinki, Finland.
Nesrin M MorsyNational Research Centre, Organometallic and Organometalloid Chemistry Department, Dokki, Cairo 12622, Egypt.ORCID 0000-0003-3636-1767
Mohammed B AlshammariCollege of Sciences and Humanities, Prince Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia.ORCID 0000-0001-9687-8747
Mahmoud A A IbrahimDepartment of Chemistry, Faculty of Science, Minia University, El Minia 61519, Egypt.ORCID 0000-0003-4819-2040
Elshimaa M N AbdelhafezDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, El Minia 61519, Egypt.
Minia University · EGKarlsruhe Institute of Technology · DENational Research Centre · EGPrince Sattam Bin Abdulaziz University · SAUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three new series of paracyclophanyl-dihydronaphtho[2,3-

Indexed as

Drug DesignAntineoplastic AgentsApoptosisCDC2 Protein KinaseCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorEnzyme InhibitorsHumansMelanomaMolecular Docking SimulationMolecular StructureNaphtholsStructure-Activity RelationshipThiazolesTumor Cells, CulturedAntineoplastic AgentsCDC2 Protein KinaseCDK1 protein, humanEnzyme InhibitorsNaphtholsThiazoles1,4-naphthoquinoneantitumorapoptosisCDK1melanomamolecular dockingparacyclophanethiazole

Identifiers

PMID33260954
PMCPMC7729638
OpenAlexW3108136555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.