Evidence map›Paper›PMID 33260945›Full record

ReviewBiosensors2020

BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes.

Sergei V Dzyuba

Open access · goldAbstract readReview
In one paragraph

Review in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Design, Synthesis, and Validation of a Novel [Molecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Sergei V DzyubaDepartment of Chemistry and Biochemistry, Texas Christian University, Fort Worth, TX 76129, USA.
Texas Christian University · US

Funding

Disrupting Protein-Protein Interactions with Self-Assembling MacrocyclesR15GM135900 · NIGMS · TEXAS CHRISTIAN UNIVERSITY · PI SIMANEK, ERIC E, STEWART, MIKAELA · 2019 to 2023
$736k
Click-fluorescent dyes for soluble amyloid oligomersR15AG038977 · NIA · TEXAS CHRISTIAN UNIVERSITY · PI DZYUBA, SERGEI · 2011 to 2011
$167k
NIA NIH HHS R15 AG038977NIGMS NIH HHS R15 GM135900NIH HHS 1R15GM135900-01
6 · The paper itself

Abstract

Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer's disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recognition of the Aβ aggregates by using small molecule-based probes and sensors should not only enhance understanding of the underlying mechanisms of amyloid formation, but also facilitate the development of therapeutic strategies to interfere with amyloid neurotoxicity. BODIPY (boron dipyrrin) dyes are among the most versatile small molecule fluorophores. BODIPY scaffolds could be functionalized to tune their photophysical properties to the desired ranges as well as to adapt these dyes to various types of conditions and environments. Thus, BODIPY dyes could be viewed as unique platforms for the design of probes and sensors that are capable of detecting and tracking structural changes of various Aβ aggregates. This review summarizes currently available examples of BODIPY dyes that have been used to investigate conformational changes of Aβ peptides, self-assembly processes of Aβ, as well as Aβ interactions with various molecules.

Indexed as

Biosensing TechniquesBoron CompoundsAlzheimer DiseaseAmyloid beta-PeptidesFluorescent DyesHumansPeptide Fragments4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAmyloid beta-PeptidesBoron CompoundsFluorescent DyesPeptide FragmentsAlzheimer’s diseaseamyloidsAβ1-42BODIPYenvironment-sensitive probesfluorescent dyesprotein folding

Identifiers

PMID33260945
PMCPMC7760207
OpenAlexW3109982942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.