ArticleBrain sciences2020
Detecting the Potential for Consciousness in Unresponsive Patients Using the Perturbational Complexity Index.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of non-invasive brain stimulation on arousal and alertness among traumatic brain injury patients with disorders of consciousness or persistent vegetative State: a systematic review.Acta neurologica Belgica · 2025Pooled it
- Perturbational complexity index in assessing responsiveness to rTMS treatment in patients with disorders of consciousness: a cross-over randomized controlled trial study.Journal of neuroengineering and rehabilitation · 2024Trial
- Covert brain complexity in the intensive care unit.Cortex; a journal devoted to the study of the nervous system and behavior · 2026Article
- Microstate permutation complexity of EEG signals distinguishes minimally conscious state plus from minimally conscious state minus.Journal of neuroengineering and rehabilitation · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- State-dependent repetitive transcranial magnetic stimulation in disorders of consciousness.Frontiers in human neuroscience · 2026Review
- Precautionary Principle and Post-Mortem Brain Resuscitation.Neuroethics · 2025Article
- Nonequilibrium brain dynamics elicited as the origin of perturbative complexity.PLoS computational biology · 2025Article
- Cortical signatures linked to behavior quantitatively track arousal levels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Utilization of Single-Pulse Transcranial-Evoked Potentials in Neurological and Psychiatric Clinical Practice: A Narrative Review.Neurology international · 2024Review
- Sleep-like cortical dynamics during wakefulness and their network effects following brain injury.Nature communications · 2024Review
- Real-time optimization to enhance noninvasive cortical excitability assessment in the human dorsolateral prefrontal cortex.bioRxiv : the preprint server for biology · 2024Article
- Transition to chaos separates learning regimes and relates to measure of consciousness in recurrent neural networks.bioRxiv : the preprint server for biology · 2024Article
- The Constrained Disorder Principle May Account for Consciousness.Brain sciences · 2024Review
- Cognitive Motor Dissociation: Gap Analysis and Future Directions.Neurocritical care · 2024Article
- Spectral peak analysis and intrinsic neural timescales as markers for the state of consciousness.NeuroImage. Clinical · 2024Article
- Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group.Neurocritical care · 2023Article
- The technology, opportunities, and challenges of Synthetic Biological Intelligence.Biotechnology advances · 2023Review
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- Measuring Consciousness in the Intensive Care Unit.Neurocritical care · 2023Article
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Authors and funding
15 authors.
Funding
Abstract
The difficulties of behavioral evaluation of prolonged disorders of consciousness (DOC) motivate the development of brain-based diagnostic approaches. The perturbational complexity index (PCI), which measures the complexity of electroencephalographic (EEG) responses to transcranial magnetic stimulation (TMS), showed a remarkable sensitivity in detecting minimal signs of consciousness in previous studies. Here, we tested the reliability of PCI in an independently collected sample of 24 severely brain-injured patients, including 11 unresponsive wakefulness syndrome (UWS), 12 minimally conscious state (MCS) patients, and 1 emergence from MCS patient. We found that the individual maximum PCI value across stimulation sites fell within the consciousness range (i.e., was higher than PCI*, which is an empirical cutoff previously validated on a benchmark population) in 11 MCS patients, yielding a sensitivity of 92% that surpassed qualitative evaluation of resting EEG. Most UWS patients (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.