Evidence map›Paper›PMID 33260896›Full record

ArticleMolecules (Basel, Switzerland)2020

Biological Properties of New Chiral 2-Methyl-5,6,7,8-tetrahydroquinolin-8-amine-based Compounds.

Giorgio Facchetti, Michael S Christodoulou, Lina Barragán Mendoza, Federico Cusinato, Lisa Dalla Via, Isabella Rimoldi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Analogues of Anticancer Natural Products: Chiral Aspects.International journal of molecular sciences · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Giorgio FacchettiDISFARM, Sezione di Chimica Generale e Organica "A. Marchesini", Università degli Studi di Milano via Venezian, 21, 20133 Milano, Italy.
Michael S ChristodoulouDISFARM, Sezione di Chimica Generale e Organica "A. Marchesini", Università degli Studi di Milano via Venezian, 21, 20133 Milano, Italy.ORCID 0000-0002-5098-3143
Lina Barragán MendozaDipartimento di Scienze del Farmaco, Università degli Studi di Padova, via F. Marzolo, 5, 35131 Padova, Italy.ORCID 0000-0003-0404-2139
Federico CusinatoDipartimento di Scienze del Farmaco, Università degli Studi di Padova, via F. Marzolo, 5, 35131 Padova, Italy.
Lisa Dalla ViaDipartimento di Scienze del Farmaco, Università degli Studi di Padova, via F. Marzolo, 5, 35131 Padova, Italy.ORCID 0000-0002-2820-4035
Isabella RimoldiDISFARM, Sezione di Chimica Generale e Organica "A. Marchesini", Università degli Studi di Milano via Venezian, 21, 20133 Milano, Italy.ORCID 0000-0002-6210-0264
University of Milan · ITUniversity of Padua · IT

Funding

Università degli Studi di Milano Piano di sostegno alla Ricerca 2019-LINEA 2.
6 · The paper itself

Abstract

The synthesis of a small library of 8-substituted 2-methyl-5,6,7,8-tetrahydroquinoline derivatives is presented. All the compounds were tested for their antiproliferative activity in non-cancer human dermal microvascular endothelial cells (HMEC-1) and cancer cells: human T-lymphocyte cells (CEM), human cervix carcinoma cells (HeLa), human dermal microvascular endothelial cells (HMEC-1), colorectal adenocarcinoma (HT-29), ovarian carcinoma (A2780), and biphasic mesothelioma (MSTO-211H). Compounds

Indexed as

Antineoplastic AgentsApoptosisCell CycleCell ProliferationCells, CulturedColorectal NeoplasmsDrug Screening Assays, AntitumorEndothelial CellsFemaleHumansMesotheliomaOvarian NeoplasmsReactive Oxygen SpeciesAntineoplastic AgentsReactive Oxygen Speciesantiproliferative activitymitochondrial damageROS productionSchiff basestetrahydroquinolines

Identifiers

PMID33260896
PMCPMC7729733
OpenAlexW3110155418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.