Evidence map›Paper›PMID 33260891›Full record

ArticleLife (Basel, Switzerland)2020

Aqueous Extract of Kan-Lu-Hsiao-Tu-Tan Ameliorates Collagen-Induced Arthritis in Mice by Inhibiting Oxidative Stress and Inflammatory Responses.

Chih-Chao Chiang, Yi-Rong Li, Kuei-Hung Lai, Wei-Jen Cheng, Shih-Chao Lin, Yi-Hsuan Wang, Po-Jen Chen, Sien-Hung Yang, Chi-Chien Lin, Tsong-Long Hwang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Life (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Chih-Chao ChiangGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Yi-Rong LiChanghua Christian Hospital, Thoracic Medicine Research Center, Changhua 500, Taiwan.
Kuei-Hung LaiResearch Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.ORCID 0000-0001-7220-6356
Wei-Jen ChengGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-5422-7097
Shih-Chao LinNational Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.ORCID 0000-0003-2942-5937
Yi-Hsuan WangGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Po-Jen ChenDepartment of Cosmetic Science, Providence University, Taichung 433, Taiwan.ORCID 0000-0002-0135-8798
Sien-Hung YangGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Chi-Chien LinInstitute of Biomedical Science, College of Life Sciences, National Chung-Hsing University, 250 Guoguang Road, Taichung 402, Taiwan.ORCID 0000-0002-1464-0231
Tsong-Long HwangResearch Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.ORCID 0000-0002-5780-3977
Chang Gung University · TWChang Gung University of Science and Technology · TWChanghua Christian Hospital · TWKaohsiung Medical University · TWMing Chi University of Technology · TWNational Taiwan Ocean University · TWProvidence University · TW

Funding

Chang Gung Memorial Hospital BMRP450Chang Gung Memorial Hospital CMRPF1F0011~3Chang Gung Memorial Hospital CMRPF1F0061~3Chang Gung Memorial Hospital CMRPF1G0241~3Chang Gung Memorial Hospital CMRPG3K0161Chang Gung University of Science and Technology ZRRPF3H0101Chang Gung University of Science and Technology ZRRPF3H0111Ministry of Science Technology MOST 104-2320-B-255-004-MY3Ministry of Science Technology MOST 106-2320-B-255-003-MY3
6 · The paper itself

Abstract

backgroundKan-Lu-Hsiao-Tu-Tan (KLHTT) exhibits anti-psoriatic effects through anti-inflammatory activity in mice. However, the therapeutic effects of KLHTT on rheumatoid arthritis (RA), another significant autoimmune inflammatory disorder, have not been elucidated. Herein, we explored the anti-arthritic effects of KLHTT on collagen-induced arthritis (CIA) in mice.

methodsKLHTT was extracted by boiling water and subjected to spectroscopic analysis. Chicken collagen type II (CII) with complete Freund's adjuvant was intradermally injected to induce CIA in DBA/1J mice. Anti-CII antibody, cytokines, malondialdehyde (MDA), and hydrogen peroxide (H

resultsOral KLHTT treatment (50 and 100 mg/kg) ameliorated mouse CIA by decreasing the levels of interleukin (IL)-1β, IL-6, IL-17A, and tumour necrosis factor-α in the paw homogenates and serum. KLHTT also suppressed anti-CII antibody formation, splenocyte proliferation, and splenic Th1 and Th17 cell numbers. Additionally, KLHTT showed antioxidant activity by reducing the concentrations of MDA and H

conclusionsThe therapeutic effects of KLHTT in CIA mice were through regulating oxidative stress and inflammatory responses. Our results suggest that KLHTT has potential to treat RA.

Indexed as

Chinese medicinecollagen-induced arthritisimmunityinflammationKan-Lu-Hsiao-Tu-Tan

Identifiers

PMID33260891
PMCPMC7760413
OpenAlexW3110321704

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.