ArticleBrain sciences2020
Amino Acid Levels as Potential Biomarker of Elderly Patients with Dementia.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 18 citations in OpenAlex.
- Trial
- Neuroprotective Effects of Lycopene in Parkinson's Disease Mice: Potential Modulation of DAT/SLC6A3-Mediated Dopaminergic Pathway.Nutrients · 2026Article
- Genetic evidence on chemical communication between gut microbiota and neurological and psychiatric disorders: a Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Marbling Matters: Lean and Fatty Red Meat Show Opposing Associations with Brain Structural Indices.Nutrients · 2026Article
- Elevated branched-chain amino acids linked to hippocampal volumes and cognitive improvement in mild cognitive impairment.Brain imaging and behavior · 2026Article
- L-α-GPC in Cognitive Decline: Mechanisms and Clinical Evidence in Neurodegenerative Disorders.Neuropsychiatric disease and treatment · 2026Review
- Deciphering the Multi-Target Therapeutic Mechanisms of Traditional Chinese Medicine Against Alzheimer's Disease: A Network Pharmacology Perspective.Drug design, development and therapy · 2026Review
- Traditional Chinese Medicine for Alzheimer's Disease: Current Evidence and Chemometric Approaches for Multi-Target Evaluation.Neuropsychiatric disease and treatment · 2026Review
- Design, Synthesis and Anti-Alzheimer's Activity of Some Hybrid Molecule of Oxymatrine Through TGF-β.Current topics in medicinal chemistry · 2026Article
- Traditional Chinese Medicine and Ferroptosis in Alzheimer's Disease: A Potential Therapeutic Approach.Drug design, development and therapy · 2026Review
- Cross-Cultural Adaptation and Psychometric Validation of the Polish Version of Rowland Universal Dementia Assessment Scale (RUDAS).Diagnostics (Basel, Switzerland) · 2025Article
- Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer's disease continuum.Metabolic brain disease · 2025Article
- Synergistic effects of surface-enhanced Raman spectroscopy and enzyme-linked immunoassays in diagnosis of Alzheimer's disease, mild cognitive impairment, and late-life depression.Frontiers in neurology · 2025Article
- The Bidirectional Mechanism of Uric Acid Levels on Alzheimer's Disease: A Narrative Review.International journal of general medicine · 2025Review
- Dysregulation ofCurrent Alzheimer research · 2024Article
- Branched-chain amino acids and the risks of dementia, Alzheimer's disease, and Parkinson's disease.Frontiers in aging neuroscience · 2024Article
- Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women.International journal of molecular sciences · 2023Article
- Identification of late-life depression and mild cognitive impairment via serum surface-enhanced Raman spectroscopy and multivariate statistical analysis.Biomedical optics express · 2023Article
- Investigating the causal association between branched-chain amino acids and Alzheimer's disease: A bidirectional Mendelian randomized study.Frontiers in nutrition · 2023Article
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Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dementia is a clinical syndrome characterized by cognitive impairment, in which there is disturbance of multiple higher cortical functions. The primary risk factor of dementia is old age, and due to significant changes in the worldwide demographic structure, the prevalence of cognitive impairment is increasing dramatically with aging populations in most countries. Alzheimer's disease is the predominant and leading cause of dementia. The aim of this study was to evaluate the modifications of amino acids that characterize the initial stages of dementia to help our understanding of the complex and multifactorial pathogenesis of neurodegenerative disorders. A total of 123 participants were divided into two groups: healthy elderly subjects and patients with mild or moderate dementia. The results of this study indicate that the serum levels of three amino acids were changed significantly in patients with dementia, in relation to the subjects without dementia. In particular, we observed differences in concentrations for serine, arginine and isoleucine (all of them were significantly increased in patients with dementia, compared with the control group). Our results suggest that the metabolisms of some amino acids seem be changed in patients with dementia. We conclude that amino acid profiling might be helpful for the better understanding of biochemical and metabolic changes related to the pathogenesis and progression of dementia. However, considering the multifactorial, heterogenous and complex nature of this disease, validation with a greater study sample in further research is required.
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