Evidence map›Paper›PMID 33260818›Full record

ArticleSensors (Basel, Switzerland)2020

All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D.

Johanna-Gabriela Walter, Lourdes S M Alwis, Bernhard Roth, Kort Bremer

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Johanna-Gabriela WalterInstitute of Technical Chemistry, Leibniz University of Hannover, 30167 Hannover, Germany.
Lourdes S M AlwisSchool of Engineering and the Built Environment, Edinburgh Napier University, Edinburgh EH10 5DT, UK.ORCID 0000-0001-8488-2992
Bernhard RothCluster of Excellence PhoenixD, (Photonics, Optics, and Engineering-Innovation Across Disciplines), 30167 Hannover, Germany.ORCID 0000-0001-9389-7125
Kort BremerCluster of Excellence PhoenixD, (Photonics, Optics, and Engineering-Innovation Across Disciplines), 30167 Hannover, Germany.

Funding

Bundesministerium für Wirtschaft und Energie 03EFHNI059Deutsche Forschungsgemeinschaft EXC 2122, Project ID 390833453Leibniz Universität Hannover Open Access Fund
6 · The paper itself

Abstract

An all-optical plasmonic sensor platform designed for smartphones based on planar-optical waveguide structures integrated in a polymer chip is reported for the first time. To demonstrate the applicability of the sensor system for biosensing purposes, the detection of 25-hydroxyvitamin D (25OHD) in human serum samples using an AuNP-enhanced aptamer-based assay was demonstrated. With the aid of the developed assay sensitivity of 0.752 pixel/nM was achieved for 25OHD concentrations ranging from 0-100 nM. The waveguide structure of the sensor enables miniaturisation and parallelisation, thus, demonstrates the potential for simultaneous detection of various analytes including biomarkers. The entire optical arrangement can be integrated into a single polymer chip which allows for large scale and cost-efficient sensor fabrication. The broad utilization and access of smartphone electronics make the proposed design most attractive for its wider use in lab-on-chip applications.

Indexed as

Biosensing TechniquesSmartphoneSurface Plasmon ResonanceVitamin DFemaleHumansPolymersPolymersVitamin Daptamersbiosensorintegrated opticsoptical waveguidesurface plasmon resonancevitamin D

Identifiers

PMID33260818
PMCPMC7730180

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.