Evidence map›Paper›PMID 33260663›Full record

ArticleInternational journal of molecular sciences2020

Knockout of the Glucocorticoid Receptor Impairs Reproduction in Female Zebrafish.

Francesca Maradonna, Giorgia Gioacchini, Valentina Notarstefano, Camilla Maria Fontana, Filippo Citton, Luisa Dalla Valle, Elisabetta Giorgini, Oliana Carnevali

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Central and Local Modulators of Reproduction and Fertility: An Update.International journal of molecular sciences · 2022
    Article
  10. Zebrafish Mutant Lines Reveal the Interplay betweenInternational journal of molecular sciences · 2022
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francesca MaradonnaDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.
Giorgia GioacchiniDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.
Valentina NotarstefanoDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.ORCID 0000-0002-4651-6235
Camilla Maria FontanaDepartment of Biology, Università di Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.ORCID 0000-0001-7520-0814
Filippo CittonDepartment of Biology, Università di Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
Luisa Dalla ValleDepartment of Biology, Università di Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.ORCID 0000-0001-8097-6369
Elisabetta GiorginiDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.
Oliana CarnevaliDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche snc, 60131 Ancona, Italy.ORCID 0000-0001-5994-0572
Marche Polytechnic University · ITUniversity of Padua · IT

Funding

Progetti di Ricerca di Ateneo 2019, Università Politecnica delle Marche 2019Progetti di Ricerca di Ateneo, University of Padova CPDA134095
6 · The paper itself

Abstract

The pleiotropic effects of glucocorticoids in metabolic, developmental, immune and stress response processes have been extensively investigated; conversely, their roles in reproduction are still less documented. It is well known that stress or long-lasting therapies can cause a strong increase in these hormones, negatively affecting reproduction. Moreover, the need of glucocorticoid (GC) homeostatic levels is highlighted by the reduced fertility reported in the zebrafish glucocorticoid receptor mutant (

Indexed as

Gene Knockout TechniquesAnimalsFemaleFertilityGene Expression RegulationOocytesOvaryReceptors, GlucocorticoidReproductionZebrafishReceptors, GlucocorticoidDanio rerioFourier transform infrared imaging spectroscopyglucocorticoidsgr mutantsoocyte maturationvitellogenesis

Identifiers

PMID33260663
PMCPMC7729492
OpenAlexW3107797020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.